Cytokines 4 Female 4 Humans 4 Male 4 Middle Aged adult 4 controlled study 4 cytokine 4 enzyme linked immunosorbent assay female 4 human 4 male 4 protein expression Adult 3 Article 3 disease severity 3 metabolism 3 middle aged 3 tumor necrosis factor 3 Aged 2 Biomarkers 2 Case-Control Studies 2 Young Adult 2 biological marker 2 case control study 2 clinical article 2 genetics 2 interleukin 12 2 interleukin 1beta 2 major clinical study 2