Adjuvants, Immunologic 1 Animals 1 Antibodies, Viral 1 Article 1 Bagg albino mouse 1 Broadly Neutralizing Antibodies 1 COVID-19 Vaccines 1 CPG-oligonucleotide 1 CpG adjuvant 1 CpG oligodeoxynucleotide 1 Fucoidan-trimethylchitosan nanoparticles 1 Immunogenicity enhancement 1 Immunogenicity, Vaccine 1 Mice 1 Mice, Inbred BALB C 1 Nanoparticles 1 Neutralizing antibody 1 Oligodeoxyribonucleotides Recombinant S1 protein 1 SARS-CoV-2 1 SARS-CoV-2 infection 1 SARS-CoV-2 recombinant S1 protein 1 SARS-CoV-2 vaccine 1 Spike Glycoprotein, Coronavirus 1 Th1 Cells 1 Th1 cell 1 Th1-biased cellular immune responses 1 Western blotting 1 animal 1 animal cell 1