3 (4,5 dimethyl 2 thiazolyl) 2,5 diphenyltetrazolium bromide 1 Adaptor Proteins, Signal Transducing 1 Animals 1 Antibiotics, Antineoplastic 1 Apoptosis 1 Article 1 Crk like protein 1 CrkL 1 CrkL gene 1 Doxorubicin 1 Drug Resistance, Neoplasm 1 Gene Expression Regulation, Neoplastic 1 Gene Silencing 1 Humans 1 IC50 1 K-562 cell line 1 K562 Cells 1 K562/Adr cell line 1 MRP1 1 MRP1 gene 1 Mice, Nude 1 Multidrug Resistance-Associated Proteins 1 PI3K Akt MRP1 signaling pathway Phosphatidylinositol 3-Kinases 1 Proto-Oncogene Proteins c-akt 1 RNA interference 1 Signal Transduction 1 Western blotting 1 Xenograft Model Antitumor Assays 1 animal 1