Article 5 Female 5 Humans 5 Middle Aged 5 Risk Factors 5 Severity of Illness Index adult 5 age controlled study 5 female 5 human 5 major clinical study middle aged 5 risk factor severity of illness index 5 Male 4 disease association 4 disease severity 4 male 4 Adult 3 Aged 3 aged 3 body mass 3 pathophysiology 3 Age Factors 2 Case-Control Studies 2 Young Adult 2 case control study 2 complication 2 confounding variable 2