Signal Transduction signal transduction 109 metabolism 80 human 76 Humans 74 genetics 57 Animals 48 animal 45 Article 44 controlled study 34 nonhuman 27 drug effect 25 Mice 21 mouse 21 male 20 physiology 20 pathology 19 Male 18 gene expression regulation 18 protein expression 18 Western blotting 17 upregulation 17 female 16 human cell 16 protein kinase B 15 animal experiment 14 Female 13 animal model 13 biological model 13 down regulation 13