adult human 428 controlled study 402 randomized controlled trial 399 female 382 male 366 Humans 346 Adult 248 Female 247 Male 230 Article 194 middle aged 163 major clinical study 150 Middle Aged 142 young adult 117 Young Adult 109 procedures 109 treatment outcome 102 aged 101 article 99 adolescent 92 Adolescent 89 Treatment Outcome 86 double blind procedure 78 human experiment 76 psychology 75 clinical article 68 Aged 67 follow up 60 outcome assessment 56