biological marker human 283 Humans 245 Biomarkers 215 Article 174 female 171 male 159 adult 136 Female 133 controlled study 130 Male 118 middle aged 99 major clinical study 91 Adult 89 Middle Aged 88 blood 80 metabolism 78 aged 69 Aged 59 genetics 50 receiver operating characteristic 45 pathology 43 sensitivity and specificity 38 procedures 37 Case-Control Studies 36 case control study 36 young adult 36 Young Adult 33 adolescent 33 priority journal 33