chemistry controlled study Article 54 nonhuman 36 unclassified drug 28 metabolism 26 human 19 Humans 18 Animals 13 animal 13 genetics 13 procedures 13 drug effect 11 chemical structure 10 molecular docking 9 molecular dynamics 9 structure activity relation 9 Fourier transform infrared spectroscopy 8 Kinetics 8 Molecular Dynamics Simulation 8 X ray diffraction 8 amino acid sequence 8 drug structure 8 in vitro study 8 kinetics 8 mouse 8 protein conformation 8 structure analysis 8 Mice 7 binding affinity 7