Automatic design 1 Bacteria 1 Bacterial genomes 1 Bartonella quintana Basic principles 1 Bioinformatic tools 1 Bioinformatics 1 Biology 1 Computational Biology 1 Computer Simulation 1 Forecasting 1 Functional annotation 1 GenBank 1 Gene essentiality 1 Genes 1 Genes, Essential 1 Genome reduction 1 Genome, Bacterial 1 Logistic Regression modeling 1 Logistic regression 1 Non-model bacteria 1 Optimal algorithm 1 Pipelines 1 Proof of concept 1 Synthetic biology chassis 1 article 1 bacterial genome 1 bacterium 1 biology 1 classifier 1