controlled study human randomized controlled trial Humans 524 female 477 male 457 adult 393 Female 340 Male 320 Adult 237 Article 206 middle aged 172 major clinical study 169 procedures 168 Middle Aged 153 young adult 130 article 129 adolescent 128 treatment outcome 126 Young Adult 123 Adolescent 122 aged 121 Treatment Outcome 108 double blind procedure 102 psychology 102 human experiment 95 Aged 89 child 88 follow up 84 clinical article 78