controlled study metabolism Article 118 pathology 111 human 101 Humans 99 male 82 female 70 Male 68 genetics 67 Female 60 unclassified drug 57 adult 56 nonhuman 55 protein expression 54 Animals 51 animal 51 human cell 50 animal experiment 46 human tissue 46 middle aged 46 Middle Aged 44 animal model 41 gene expression regulation 39 animal tissue 38 major clinical study 38 immunohistochemistry 32 aged 31 gene expression 31 mouse 31