controlled study Article 169 metabolism 156 human 131 Humans 117 nonhuman 99 genetics 97 male 91 unclassified drug 84 female 76 Animals 73 animal 72 protein expression 69 gene expression regulation 67 adult 66 human cell 64 animal experiment 61 Male 60 upregulation 59 gene expression 57 pathology 57 down regulation 56 Female 55 animal model 48 mouse 47 animal tissue 43 human tissue 43 animal cell 42 cell proliferation 39 signal transduction 39