diagnostic test accuracy study sensitivity and specificity human 127 Article 121 controlled study 110 Humans 96 female 88 adult 85 major clinical study 80 male 79 receiver operating characteristic 65 Female 55 middle aged 52 Male 50 diagnostic accuracy 48 Middle Aged 43 aged 41 procedures 40 predictive value 33 Adult 32 diagnostic value 32 blood 30 Sensitivity and Specificity 27 Aged 25 unclassified drug 25 genetics 24 prognosis 24 area under the curve 23 human tissue 23 pathology 21