disease association human 144 major clinical study Article 142 female 140 male 134 adult 119 Humans 111 controlled study 105 Female 85 Male 80 middle aged 78 aged 65 Middle Aged 63 Adult 62 risk factor 49 Aged 37 cohort analysis 36 adolescent 34 disease severity 34 complication 33 follow up 32 cross-sectional study 30 young adult 29 retrospective study 28 Adolescent 27 prevalence 26 priority journal 26 case control study 25 Young Adult 24