Bioinformatics 1 CRISPR Cas system 1 Common variant 1 Gene therapy 1 Genomics 1 Precision medicine 1 RNA sequencing 1 Rare variant 1 Review 1 Statistical genetics 1 autosomal recessive inheritance 1 cohort allelic sums test 1 combined multivariate and collapsing test 1 computational genomics 1 congenital malformation 1 gene therapy 1 gene-based association test genetic analysis 1 genetic variability 1 genome-wide association study 1 genomics 1 genotype 1 human 1 inheritance 1 kernel-based adaptive clustering method 1 machine learning 1 multi-trait analysis of rare variant association 1 personalized medicine 1 random forest 1 risk assessment 1