Article 2 health care system human 2 Biosimilar Pharmaceuticals 1 Burden of disease 1 Delivery of Health Care, Integrated 1 Essential medicines list 1 Food and Drug Administration 1 Health Policy 1 Healthcare budget 1 Humans 1 Insurance Coverage 1 Insurance, Pharmaceutical Services 1 Pharmaceutical expenditure 1 Product Surveillance, Postmarketing 1 South Africa 1 Standard treatment guidelines 1 United States 1 United States Food and Drug Administration 1 advertising 1 biological therapy 1 biosimilar agent 1 budget 1 clinical assessment 1 clinical decision making 1 clinical practice 1 decision making 1 disease burden 1 drug cost 1 drug manufacture 1