human upregulation Article 69 Humans 66 controlled study 60 genetics 57 down regulation 46 unclassified drug 45 female 41 human cell 41 gene expression regulation 40 metabolism 39 male 38 adult 35 gene expression 35 pathology 34 Female 32 Gene Expression Regulation, Neoplastic 32 human tissue 31 Male 30 cell proliferation 30 protein expression 29 Up-Regulation 24 major clinical study 24 real time polymerase chain reaction 24 Cell Line, Tumor 23 Cell Proliferation 23 tumor cell line 23 Western blotting 22 apoptosis 21