human Article 5 Humans 5 drug synthesis 5 structure activity relation 5 unclassified drug 4 Structure-Activity Relationship 3 chemistry 3 human cell 3 medicinal chemistry 3 proton nuclear magnetic resonance 3 Animals 2 Chemistry, Pharmaceutical 2 Cytotoxicity 2 Dose-Response Relationship, Drug 2 IC50 2 MTT assay 2 Molecular Structure 2 animal 2 article 2 cancer cell culture 2 carbon nuclear magnetic resonance 2 carbonate dehydratase inhibitor 2 chemical structure 2 computer model 2 controlled study 2 cyclooxygenase 2 2 dose response 2 drug cytotoxicity 2 drug effects 2