Article 10 biological marker human 10 major clinical study Humans 9 controlled study 9 adult 8 receiver operating characteristic 8 Biomarkers 7 female 7 male 7 sensitivity and specificity 6 Female 4 ROC Curve 4 blood 4 middle aged 4 scoring system 4 Adult 3 Case-Control Studies 3 Male 3 Middle Aged 3 Prognosis 3 case control study 3 cohort analysis 3 diagnostic test accuracy study 3 machine learning 3 prediction 3 prognosis 3 protein expression 3 retrospective study 3