metabolism human 154 Humans 152 Article 141 controlled study 122 male 104 female 99 adult 91 Male 90 Female 89 genetics 89 middle aged 68 pathology 67 major clinical study 66 Middle Aged 65 unclassified drug 57 human cell 55 aged 47 human tissue 45 Adult 43 Aged 43 gene expression 43 gene expression regulation 43 protein expression 42 blood 36 prognosis 36 upregulation 35 Western blotting 34 Prognosis 33 Animals 32