Androgen antagonists 1 Article 1 Nonmetastatic castration-resistant prostate cancer 1 Prostate-specific antigen kinetics 1 Prostatic neoplasm 1 adult 1 adverse event 1 androgen deprivation therapy 1 apalutamide 1 cancer patient 1 cancer prognosis 1 cancer survival 1 castration resistant prostate cancer 1 clinical outcome 1 controlled study 1 human 1 kinetics 1 major clinical study 1 male 1 metastasis free survival overall survival 1 phase 3 clinical trial 1 placebo 1 prostate cancer 1 prostate specific antigen 1 randomized controlled trial 1 treatment outcome 1