CRISPR-CAS9 system 1 RNA sequencing 1 RNA-seq 1 adolescent 1 animal experiment 1 article 1 cold stress 1 controlled study 1 differential gene expression 1 differentially expressed genes 1 exocrine gland 1 female 1 fertilization 1 gene deletion 1 gene editing 1 gene expression 1 gene mutation 1 genetic transcription 1 gpr56 1 homozygote 1 in situ hybridization 1 innate immunity 1 juvenile 1 knockout 1 knockout gene 1 male 1 motor ability motor function test 1 nonhuman 1 pancreas 1