pathology human 180 Humans 177 Article 140 controlled study 126 male 115 metabolism 109 unclassified drug 99 Male 98 female 98 genetics 90 Female 87 Animals 80 animal 80 adult 77 drug effect 63 middle aged 62 nonhuman 61 Middle Aged 59 human cell 51 animal experiment 50 human tissue 49 major clinical study 49 gene expression regulation 48 protein expression 43 cell proliferation 41 mouse 41 animal model 40 Cell Line, Tumor 39 tumor cell line 39