Cell culture 1 Chemical activation 1 Dermal fibroblasts 1 Dermal wound healing 1 Extracellular matrix deposition 1 Fibroblasts 1 Fibrose 1 Homoeostasis 1 Normal function 1 Oxidative stress 1 PI3K/Akt pathways 1 PI3K/akt pathway 1 Porous se@SiO2 nanoparticle 1 Scar formation 1 SiO2 nanoparticles 1 Silica nanoparticles 1 Silicon 1 Synthesis (chemical) 1 Tissue regeneration 1 Wound healing 1 fibrosis 1 oxidative stress 1 porous se@SiO2 nanoparticles wound healing 1