statistical power Article 1 Bayes Theorem 1 Bayes theorem 1 Biomarkers 1 Computer Simulation 1 Humans 1 Monte Carlo simulation 1 Random Allocation 1 Research Design 1 adaptive design 1 adaptive randomisation 1 adaptive randomization 1 bias 1 biological marker 1 clinical trial protocol 1 comparative effectiveness 1 computer simulation 1 constrained randomisation 1 constrained randomization 1 controlled study 1 disease marker 1 hierarchical linear modeling 1 human 1 hypothesis 1 intermethod comparison 1 mean square error 1 methodology 1 patient allocation 1 personalized medicine 1