unclassified drug Article 157 controlled study 139 nonhuman 110 human 89 Humans 69 metabolism 65 male 57 chemistry 52 enzyme activity 51 Animals 44 female 40 human cell 40 animal 39 animal experiment 39 Male 38 enzyme inhibition 36 enzyme linked immunosorbent assay 36 drug effect 35 IC50 34 protein expression 34 plant extract 32 adult 31 genetics 31 animal tissue 29 in vitro study 29 priority journal 29 rat 27 animal model 26 Female 25