upregulation Article 144 controlled study 134 human 128 Humans 95 male 84 down regulation 82 genetics 80 unclassified drug 80 nonhuman 74 metabolism 73 female 71 gene expression 66 adult 63 protein expression 61 human cell 59 Male 51 Female 49 gene expression regulation 48 pathology 48 animal experiment 46 cell proliferation 43 human tissue 42 real time polymerase chain reaction 41 signal transduction 41 animal model 39 Western blotting 38 major clinical study 36 Animals 35 apoptosis 35