Nucleolar stress in C9orf72 and sporadic ALS spinal motor neurons precedes TDP-43 mislocalization

by Olubankole Aladesuyi Arogundade, Sandra Nguyen, Ringo Leung, Danielle Wainio, Maria Rodriguez, John Ravits
Published 2021-02-01

Iron loading is a prominent feature of activated microglia in Alzheimer’s disease patients

by Boyd Kenkhuis, Antonios Somarakis, Lorraine de Haan, Oleh Dzyubachyk, Marieke E. IJsselsteijn, Noel F. C. C. de Miranda, Boudewijn P. F. Lelieveldt, Jouke Dijkstra, Willeke M. C. van Roon-Mom, Thomas Höllt, Louise van der Weerd
Published 2021-02-01

Tau-proximity ligation assay reveals extensive previously undetected pathology prior to neurofibrillary tangles in preclinical Alzheimer’s disease

by Nora Bengoa-Vergniory, Elisavet Velentza-Almpani, Ana Maria Silva, Connor Scott, Mariana Vargas-Caballero, Magdalena Sastre, Richard Wade-Martins, Javier Alegre-Abarrategui
Published 2021-01-01

Prion-induced photoreceptor degeneration begins with misfolded prion protein accumulation in cones at two distinct sites: cilia and ribbon synapses

by James F. Striebel, Brent Race, Jacqueline M. Leung, Cindi Schwartz, Bruce Chesebro
Published 2021-01-01

A robust TDP-43 knock-in mouse model of ALS

by Shih-Ling Huang, Lien-Szu Wu, Min Lee, Chin-Wen Chang, Wei-Cheng Cheng, Yu-Sheng Fang, Yun-Ru Chen, Pei-Lin Cheng, Che-Kun James Shen
Published 2020-01-01

N-acetylcysteine inhibits bacterial lipopeptide-mediated neutrophil transmigration through the choroid plexus in the developing brain

by Amin Mottahedin, Sandrine Blondel, Joakim Ek, Anna-Lena Leverin, Pernilla Svedin, Henrik Hagberg, Carina Mallard, Jean-Francois Ghersi-Egea, Nathalie Strazielle
Published 2020-01-01

Glioma cells require one-carbon metabolism to survive glutamine starvation

by Kazuhiro Tanaka, Takashi Sasayama, Hiroaki Nagashima, Yasuhiro Irino, Masatomo Takahashi, Yoshihiro Izumi, Takiko Uno, Naoko Satoh, Akane Kitta, Katsusuke Kyotani, Yuichi Fujita, Mitsuru Hashiguchi, Tomoaki Nakai, Masaaki Kohta, Yoichi Uozumi, Masakazu Shinohara, Kohkichi Hosoda, Takeshi Bamba, Eiji Kohmura
Published 2021-01-01

Spreading of TDP-43 pathology via pyramidal tract induces ALS-like phenotypes in TDP-43 transgenic mice

by Xuebing Ding, Zhi Xiang, Chi Qin, Yongkang Chen, Haiyan Tian, Lin Meng, Danhao Xia, Han Liu, Jia Song, Jun Fu, Mingming Ma, Xuejing Wang
Published 2021-01-01

H3F3A mutant allele specific imbalance in an aggressive subtype of diffuse midline glioma, H3 K27M-mutant

by Sachi Maeda, Fumiharu Ohka, Yusuke Okuno, Kosuke Aoki, Kazuya Motomura, Kazuhito Takeuchi, Hironao Kusakari, Nobuyuki Yanagisawa, Shinya Sato, Junya Yamaguchi, Kuniaki Tanahashi, Masaki Hirano, Akira Kato, Hiroyuki Shimizu, Yotaro Kitano, Shintaro Yamazaki, Shinji Yamashita, Hideo Takeshima, Keiko Shinjo, Yutaka Kondo, Toshihiko Wakabayashi, Atsushi Natsume
Published 2020-02-01

Genetic and histologic spatiotemporal evolution of recurrent, multifocal, multicentric and metastatic glioblastoma

by Maria-Magdalena Georgescu, Adriana Olar
Published 2020-02-01

Inflammation of the choroid plexus in progressive multiple sclerosis: accumulation of granulocytes and T cells

by Sabela Rodríguez-Lorenzo, Julia Konings, Susanne van der Pol, Alwin Kamermans, Sandra Amor, Jack van Horssen, Maarten E. Witte, Gijs Kooij, Helga E. de Vries
Published 2020-02-01

Molecular analysis of pediatric CNS-PNET revealed nosologic heterogeneity and potent diagnostic markers for CNS neuroblastoma with FOXR2-activation

by Andrey Korshunov, Konstantin Okonechnikov, Felix Schmitt-Hoffner, Marina Ryzhova, Felix Sahm, Damian Stichel, Daniel Schrimpf, David E. Reuss, Philipp Sievers, Abigail Kora Suwala, Ella Kumirova, Olga Zheludkova, Andrey Golanov, David T. W. Jones, Stefan M. Pfister, Marcel Kool, Andreas von Deimling
Published 2021-02-01

Neuroligin-1 in brain and CSF of neurodegenerative disorders: investigation for synaptic biomarkers

by Elena Camporesi, Tammaryn Lashley, Johan Gobom, Juan Lantero-Rodriguez, Oskar Hansson, Henrik Zetterberg, Kaj Blennow, Bruno Becker
Published 2021-02-01

Non-cell autonomous astrocyte-mediated neuronal toxicity in prion diseases

by Rajesh Kushwaha, Anshuman Sinha, Natallia Makarava, Kara Molesworth, Ilia V. Baskakov
Published 2021-02-01

Protein disulfide isomerase ERp57 protects early muscle denervation in experimental ALS

by Pablo Rozas, Cristina Pinto, Francisca Martínez Traub, Rodrigo Díaz, Viviana Pérez, Daniela Becerra, Patricia Ojeda, Jorge Ojeda, Madison T. Wright, Jessica Mella, Lars Plate, Juan Pablo Henríquez, Claudio Hetz, Danilo B. Medinas
Published 2021-02-01

Pre-clinical characterisation of E2814, a high-affinity antibody targeting the microtubule-binding repeat domain of tau for passive immunotherapy in Alzheimer’s disease

by Malcolm Roberts, Ioanna Sevastou, Yoichi Imaizumi, Kavita Mistry, Sonia Talma, Madhurima Dey, Jane Gartlon, Hiroshi Ochiai, Zhi Zhou, Shigeru Akasofu, Naoki Tokuhara, Makoto Ogo, Muneo Aoyama, Hirofumi Aoyagi, Kate Strand, Ezat Sajedi, Kishan Lal Agarwala, Jared Spidel, Earl Albone, Kanta Horie, James M. Staddon, Rohan de Silva
Published 2020-02-01

Thalamostriatal degeneration contributes to dystonia and cholinergic interneuron dysfunction in a mouse model of Huntington’s disease

by Gabriel Crevier-Sorbo, Vladimir V. Rymar, Raphael Crevier-Sorbo, Abbas F. Sadikot
Published 2020-02-01

Locus coeruleus pathology in progressive supranuclear palsy, and its relation to disease severity

by Sanne Simone Kaalund, Luca Passamonti, Kieren S. J. Allinson, Alexander G. Murley, Trevor W. Robbins, Maria Grazia Spillantini, James B. Rowe
Published 2020-02-01

Tau-tubulin kinase 1 and amyloid-β peptide induce phosphorylation of collapsin response mediator protein-2 and enhance neurite degeneration in Alzheimer disease mouse models

by Seiko Ikezu, Kaitlin L. Ingraham Dixie, Lacin Koro, Takashi Watanabe, Kozo Kaibuchi, Tsuneya Ikezu
Published 2020-02-01

Laterality and region-specific tau phosphorylation correlate with PTSD-related behavioral traits in rats exposed to repetitive low-level blast

by Georgina Perez Garcia, Rita De Gasperi, Miguel A. Gama Sosa, Gissel M. Perez, Alena Otero-Pagan, Dylan Pryor, Rania Abutarboush, Usmah Kawoos, Patrick R. Hof, Dara L. Dickstein, David G. Cook, Sam Gandy, Stephen T. Ahlers, Gregory A. Elder
Published 2021-03-01