p53–GSDME Elevation: A Path for CDK7 Inhibition to Suppress Breast Cancer Cell Survival

by Yueyuan Wang, Jingyu Peng, Xuguang Mi, Ming Yang
Published 2021-08-01

CDK7 Inhibition is Effective in all the Subtypes of Breast Cancer: Determinants of Response and Synergy with EGFR Inhibition

by Martina S.J. McDermott, Amanda C. Sharko, Jessica Munie, Susannah Kassler, Theresa Melendez, Chang-uk Lim, Eugenia V. Broude
Published 2020-03-01

Efficacy of the CDK7 Inhibitor on EMT-Associated Resistance to 3rd Generation EGFR-TKIs in Non-Small Cell Lung Cancer Cell Lines

by Wonjun Ji, Yun Jung Choi, Myoung-Hee Kang, Ki Jung Sung, Dong Ha Kim, Sangyong Jung, Chang-Min Choi, Jae Cheol Lee, Jin Kyung Rho
Published 2020-12-01

Targeting Super‐Enhancers via Nanoparticle‐Facilitated BRD4 and CDK7 Inhibitors Synergistically Suppresses Pancreatic Ductal Adenocarcinoma

by Chen‐Song Huang, Xinru You, Chunlei Dai, Qiong‐Cong Xu, Fuxi Li, Li Wang, Xi‐Tai Huang, Jie‐Qin Wang, Shi‐Jin Li, Zhuoxing Gao, Jun Wu, Xiao‐Yu Yin, Wei Zhao
Published 2020-04-01

CDK7 inhibitor suppresses tumor progression through blocking the cell cycle at the G2/M phase and inhibiting transcriptional activity in cervical cancer

by Zhong S, Zhang Y, Yin X, Di W
Published 2019-03-01

CDK7 inhibition is a novel therapeutic strategy against GBM both in vitro and in vivo

by Meng W, Wang J, Wang B, Liu F, Li M, Zhao Y, Zhang C, Li Q, Chen J, Zhang L, Tang Y, Ma J
Published 2018-11-01

Identification of CDK7 Inhibitors from Natural Sources Using Pharmacoinformatics and Molecular Dynamics Simulations

by Vikas Kumar, Shraddha Parate, Gunjan Thakur, Gihwan Lee, Hyeon-Su Ro, Yongseong Kim, Hong Ja Kim, Myeong Ok Kim, Keun Woo Lee
Published 2021-09-01

Hippo-Independent Regulation of Yki/Yap/Taz: A Non-canonical View

by Yong Suk Cho, Jin Jiang, Jin Jiang
Published 2021-04-01

Selective CDK7 inhibition with BS-181 suppresses cell proliferation and induces cell cycle arrest and apoptosis in gastric cancer

by Wang BY, Liu QY, Cao J, Chen JW, Liu ZS
Published 2016-03-01

Targeting MYC dependency in ovarian cancer through inhibition of CDK7 and CDK12/13

by Mei Zeng, Nicholas P Kwiatkowski, Tinghu Zhang, Behnam Nabet, Mousheng Xu, Yanke Liang, Chunshan Quan, Jinhua Wang, Mingfeng Hao, Sangeetha Palakurthi, Shan Zhou, Qing Zeng, Paul T Kirschmeier, Khyati Meghani, Alan L Leggett, Jun Qi, Geoffrey I Shapiro, Joyce F Liu, Ursula A Matulonis, Charles Y Lin, Panagiotis A Konstantinopoulos, Nathanael S Gray
Published 2018-11-01

Therapeutic Targeting of the General RNA Polymerase II Transcription Machinery

by Ryan D. Martin, Terence E. Hébert, Jason C. Tanny
Published 2020-05-01

Cdk7 Is Required for Activity-Dependent Neuronal Gene Expression, Long-Lasting Synaptic Plasticity and Long-Term Memory

by Guiqin He, Xiangyu Yang, Guo Wang, Junxia Qi, Rui Mao, Zhengping Wu, Zikai Zhou, Zikai Zhou
Published 2017-11-01

CDK7 and miR-210 Co-regulate Cell-Cycle Progression of Neural Progenitors in the Developing Neocortex

by Aisha I. Abdullah, Haijun Zhang, Yanzhen Nie, Wei Tang, Tao Sun
Published 2016-07-01

Systematic Characterization of Recurrent Genomic Alterations in Cyclin-Dependent Kinases Reveals Potential Therapeutic Strategies for Cancer Treatment

by Weiwei Shan, Jiao Yuan, Zhongyi Hu, Junjie Jiang, Yueying Wang, Nicki Loo, Lingling Fan, Zhaoqing Tang, Tianli Zhang, Mu Xu, Yutian Pan, Jiaqi Lu, Meixiao Long, Janos L. Tanyi, Kathleen T. Montone, Yi Fan, Xiaowen Hu, Youyou Zhang, Lin Zhang
Published 2020-07-01

Targeting General Transcriptional Machinery as a Therapeutic Strategy for Adult T-Cell Leukemia

by Regina Wan Ju Wong, Takashi Ishida, Takaomi Sanda
Published 2018-05-01

Perturbing Enhancer Activity in Cancer Therapy

by Feda H. Hamdan, Steven A. Johnsen
Published 2019-05-01

CDK7 Inhibitor THZ1 Induces the Cell Apoptosis of B-Cell Acute Lymphocytic Leukemia by Perturbing Cellular Metabolism

by Tuersunayi Abudureheman, Jing Xia, Jing Xia, Ming-Hao Li, Ming-Hao Li, Hang Zhou, Hang Zhou, Wei-Wei Zheng, Neng Zhou, Rong-Yi Shi, Jian-Min Zhu, Li-Ting Yang, Li Chen, Liang Zheng, Kai Xue, Kai Qing, Cai-Wen Duan, Cai-Wen Duan, Cai-Wen Duan
Published 2021-04-01

CDK7 inhibitor THZ1 enhances antiPD-1 therapy efficacy via the p38α/MYC/PD-L1 signaling in non-small cell lung cancer

by Jian Wang, Ruiguang Zhang, Zhenyu Lin, Sheng Zhang, Yaobing Chen, Jing Tang, Jiaxin Hong, Xiaoshu Zhou, Yan Zong, Yingzhuo Xu, Rui Meng, Shuangbing Xu, Li Liu, Tao Zhang, Kunyu Yang, Xiaorong Dong, Gang Wu
Published 2020-07-01

Gambogic Acid Inhibits the Progression of Gastric Cancer via circRNA_ASAP2/miR-33a-5p/CDK7 Axis

by Lin D, Lin X, He T, Xie G
Published 2020-09-01