Physiologically‐Based Pharmacokinetic Model‐Informed Drug Development for Fenebrutinib: Understanding Complex Drug‐Drug Interactions

by Yuan Chen, Fang Ma, Nicholas S. Jones, Kenta Yoshida, Po‐Chang Chiang, Matthew R. Durk, Matthew R. Wright, Jin Yan Jin, Leslie W. Chinn
Published 2020-06-01

Mining the Synergistic Core Allosteric Modules Variation and Sequencing Pharmacological Module Drivers in a Preclinical Model of Ischemia

by Yingying Zhang, Zide Zhao, Yanan Yu, Jun Liu, Pengqian Wang, Bing Li, Xiaoxu Zhang, Yinying Chen, Zhong Wang
Published 2018-04-01

Assessing Similarity Among Individual Tumor Size Lesion Dynamics: The CICIL Methodology

by Nadia Terranova, Pascal Girard, Konstantinos Ioannou, Ute Klinkhardt, Alain Munafo
Published 2018-04-01

NONMEM Tutorial Part I: Description of Commands and Options, With Simple Examples of Population Analysis

by Robert J. Bauer
Published 2019-08-01

A Theoretical Physiologically‐Based Pharmacokinetic Approach to Ascertain Covariates Explaining the Large Interpatient Variability in Tacrolimus Disposition

by Chie Emoto, Trevor N. Johnson, David Hahn, Uwe Christians, Rita R. Alloway, Alexander A. Vinks, Tsuyoshi Fukuda
Published 2019-05-01

A Review of Mathematical Models for Tumor Dynamics and Treatment Resistance Evolution of Solid Tumors

by Anyue Yin, Dirk Jan A.R. Moes, Johan G.C. vanHasselt, Jesse J. Swen, Henk‐Jan Guchelaar
Published 2019-10-01

Recruiting the Immune System Against Disease: Lessons for Clinical and Systems Pharmacology

by Paolo Vicini, Nathan Standifer, Timothy P. Hickling
Published 2019-07-01

Pharmacometrics in Australasia—Twenty Years of Population Approach Group of Australia and New Zealand

by Stefanie Hennig, Jacqueline A. Hannam, Carl M.J. Kirkpatrick, Christine E. Staatz, Sam Holford, Stephen B. Duffull, Hesham S. Al‐Sallami, Bruce G. Charles, Nick Holford, David J.R. Foster
Published 2019-10-01

Modeling Tumor Growth and Treatment Resistance Dynamics Characterizes Different Response to Gefitinib or Chemotherapy in Non‐Small Cell Lung Cancer

by Mario Nagase, Sergey Aksenov, Hong Yan, James Dunyak, Nidal Al‐Huniti
Published 2020-03-01

Application of Physiologically‐Based and Population Pharmacokinetic Modeling for Dose Finding and Confirmation During the Pediatric Development of Moxifloxacin

by Stefan Willmann, Matthias Frei, Gabriele Sutter, Katrin Coboeken, Thomas Wendl, Thomas Eissing, Jörg Lippert, Heino Stass
Published 2019-09-01

Pediatric Dosing of Ganciclovir and Valganciclovir: How Model‐Based Simulations Can Prevent Underexposure and Potential Treatment Failure

by Karin Jorga, Bruno Reigner, Clarisse Chavanne, Giuseppe Alvaro, Nicolas Frey
Published 2019-03-01

Population Pharmacokinetics of Intravenous Artesunate: A Pooled Analysis of Individual Data From Patients With Severe Malaria

by S G Zaloumis, J Tarning, S Krishna, R N Price, N J White, T M E Davis, J M McCaw, P Olliaro, R J Maude, P Kremsner, A Dondorp, M Gomes, K Barnes, J A Simpson
Published 2014-11-01

Where Do PBPK Models Stand in Pharmacometrics and Systems Pharmacology?

by Masoud Jamei
Published 2020-02-01

Tumor Time‐Course Predicts Overall Survival in Non‐Small Cell Lung Cancer Patients Treated with Atezolizumab: Dependency on Follow‐Up Time

by Ida Netterberg, René Bruno, Ya‐Chi Chen, Helen Winter, Chi‐Chung Li, Jin Y. Jin, Lena E. Friberg
Published 2020-02-01

Evaluating the Role of Janus Kinase Pathways in Platelet Homeostasis Using a Systems Modeling Approach

by Sarita Koride, Satyaprakash Nayak, Christopher Banfield, Mark C. Peterson
Published 2019-07-01

Differentiating the Sodium‐Glucose Cotransporter 1 Inhibition Capacity of Canagliflozin vs. Dapagliflozin and Empagliflozin Using Quantitative Systems Pharmacology Modeling

by Victor Sokolov, Tatiana Yakovleva, Lulu Chu, Weifeng Tang, Peter J. Greasley, Susanne Johansson, Kirill Peskov, Gabriel Helmlinger, David W. Boulton, Robert C. Penland
Published 2020-04-01

Time‐Varying Clearance and Impact of Disease State on the Pharmacokinetics of Avelumab in Merkel Cell Carcinoma and Urothelial Carcinoma

by Justin J. Wilkins, Brigitte Brockhaus, Haiqing Dai, Yulia Vugmeyster, Joleen T. White, Satjit Brar, Carlo L. Bello, Berend Neuteboom, Janet R. Wade, Pascal Girard, Akash Khandelwal
Published 2019-06-01

Quantitative Systems Pharmacology: A Regulatory Perspective on Translation

by Issam Zineh
Published 2019-06-01

Power Determination During Drug Development: Is Optimizing the Sample Size Based on Exposure‐Response Analyses Underutilized?

by Aksana K. Jones, Ahmed Hamed Salem, Kevin J. Freise
Published 2019-03-01

Optimal Scheduling of Bevacizumab and Pemetrexed/Cisplatin Dosing in Non‐Small Cell Lung Cancer

by Benjamin K. Schneider, Arnaud Boyer, Joseph Ciccolini, Fabrice Barlesi, Kenneth Wang, Sebastien Benzekry, Jonathan P. Mochel
Published 2019-08-01