A Mechanistic Systems Pharmacology Model for Prediction of LDL Cholesterol Lowering by PCSK9 Antagonism in Human Dyslipidemic Populations

by K Gadkar, N Budha, A Baruch, J D Davis, P Fielder, S Ramanujan
Published 2014-11-01

Machine Learning in Drug Discovery and Development Part 1: A Primer

by Alan Talevi, Juan Francisco Morales, Gregory Hather, Jagdeep T. Podichetty, Sarah Kim, Peter C. Bloomingdale, Samuel Kim, Jackson Burton, Joshua D. Brown, Almut G. Winterstein, Stephan Schmidt, Jensen Kael White, Daniela J. Conrado
Published 2020-03-01

A Citrulline‐Based Translational Population System Toxicology Model for Gastrointestinal‐Related Adverse Events Associated With Anticancer Treatments

by Tomoki Yoneyama, Kojo Abdul‐Hadi, Adam Brown, Emily Guan, Matt Wagoner, Andy Z.X. Zhu
Published 2019-12-01

Parametric Time‐to‐Event Model for Acute Exacerbations in Idiopathic Pulmonary Fibrosis

by Fei Tang, Benjamin Weber, Susanne Stowasser, Julia Korell
Published 2020-02-01

Pharmacometrics and/or Systems Pharmacology

by Piet H. van derGraaf
Published 2019-06-01

Artificial Intelligence and Pharmacometrics: Time to Embrace, Capitalize, and Advance?

by Ayyappa Chaturvedula, Stacie Calad‐Thomson, Chao Liu, Mark Sale, Nandu Gattu, Navin Goyal
Published 2019-07-01

Precision dosing of intravenous busulfan in pediatric hematopoietic stem cell transplantation: Results from a multicenter population pharmacokinetic study

by Khalil Ben Hassine, Tiago Nava, Yves Théoret, Christa E. Nath, Youssef Daali, Nastya Kassir, Victor Lewis, Robbert G. M. Bredius, Peter J. Shaw, Henrique Bittencourt, Maja Krajinovic, Chakradhara Rao Satyanarayana Uppugunduri, Marc Ansari
Published 2021-09-01

Random control selection for conducting high‐throughput adverse drug events screening using large‐scale longitudinal health data

by Chien‐Wei Chiang, Penyue Zhang, Macarius Donneyong, You Chen, Yu Su, Lang Li
Published 2021-09-01

Network module‐based drug repositioning for pulmonary arterial hypertension

by Rui‐Sheng Wang, Joseph Loscalzo
Published 2021-09-01

Cytochrome P450 2D6 genotype–phenotype characterization through population pharmacokinetic modeling of tedatioxetine

by Trine Frederiksen, Johan Areberg, Ellen Schmidt, Tore Bjerregaard Stage, Kim Brøsen
Published 2021-09-01

Using physiologically‐based pharmacokinetic modeling for predicting the effects of hepatic impairment on the pharmacokinetics of olanzapine and samidorphan given as a combination t...

by Lei Sun, Zoe Barter, Lisa vonMoltke, Karen Rowland Yeo
Published 2021-09-01

V2ACHER: Visualization of complex trial data in pharmacometric analyses with covariates

by Jos Lommerse, Nele Plock, S. Y. Amy Cheung, Jeffrey R. Sachs
Published 2021-09-01

Estimating fetal exposure to the P‐gp substrates, corticosteroids, by PBPK modeling to inform prevention of neonatal respiratory distress syndrome

by Olena Anoshchenko, Mark A. Milad, Jashvant D. Unadkat
Published 2021-09-01

Model‐based meta‐analysis of changes in circulatory system physiology in patients with chronic heart failure

by Ryota Takaoka, Yukako Soejima, Sayuri Guro, Hideki Yoshioka, Hiromi Sato, Hiroshi Suzuki, Akihiro Hisaka
Published 2021-09-01

Quantitative prediction of breast cancer resistant protein mediated drug‐drug interactions using physiologically‐based pharmacokinetic modeling

by Chester Costales, Jian Lin, Emi Kimoto, Shinji Yamazaki, James R. Gosset, A. David Rodrigues, Sarah Lazzaro, Mark A. West, Michael West, Manthena V. S. Varma
Published 2021-09-01

A best practice framework for applying physiologically‐based pharmacokinetic modeling to pediatric drug development

by Trevor N. Johnson, Ben G. Small, Eva Gil Berglund, Karen Rowland Yeo
Published 2021-09-01

Prediction of the drug–drug interaction potential of the α1‐acid glycoprotein bound, CYP3A4/CYP2C9 metabolized oncology drug, erdafitinib

by Loeckie De Zwart, Jan Snoeys, Frank Jacobs, Lilian Y. Li, Italo Poggesi, Peter Verboven, Ivo Goris, Ellen Scheers, Inneke Wynant, Mario Monshouwer, Rao N. V. S. Mamidi
Published 2021-09-01

Anti–SARS‐CoV‐2 Repurposing Drug Database: Clinical Pharmacology Considerations

by Xinyuan Zhang, Yuching Yang, Manuela Grimstein, Guansheng Liu, Eliford Kitabi, Jianghong Fan, Ying‐Hong Wang, Justin Earp, James L. Weaver, Hao Zhu, Jiang Liu, Kellie S. Reynolds, Shiew‐Mei Huang, Yaning Wang
Published 2021-09-01

Application of a dual mechanistic approach to support bilastine dose selection for older adults

by Chaejin Kim, Valentina Lo Re, Monica Rodriguez, John C. Lukas, Nerea Leal, Cristina Campo, Aintzane García‐Bea, Elena Suarez, Stephan Schmidt, Valvanera Vozmediano
Published 2021-09-01

Network model‐based screen for FDA‐approved drugs affecting cardiac fibrosis

by Angela C. Zeigler, Anirudha S. Chandrabhatla, Steven L. Christiansen, Anders R. Nelson, Jeffrey W. Holmes, Jeffrey J. Saucerman
Published 2021-04-01