Timing of Antiviral Treatment Initiation is Critical to Reduce SARS‐CoV‐2 Viral Load

by Antonio Gonçalves, Julie Bertrand, Ruian Ke, Emmanuelle Comets, Xavier deLamballerie, Denis Malvy, Andrés Pizzorno, Olivier Terrier, Manuel Rosa Calatrava, France Mentré, Patrick Smith, Alan S. Perelson, Jérémie Guedj
Published 2020-09-01

Physiologically Based Pharmacokinetic Modeling and Simulation in Pediatric Drug Development

by A R Maharaj, A N Edginton
Published 2014-11-01

Development of a Pharmacokinetic Model Describing Neonatal Fc Receptor‐Mediated Recycling of HL2351, a Novel Hybrid Fc‐Fused Interleukin‐1 Receptor Antagonist, to Optimize Dosage R...

by Lien Ngo, Jaeseong Oh, Anhye Kim, Hyun‐moon Back, Won‐ho Kang, Jung‐woo Chae, Hwi‐yeol Yun, Howard Lee
Published 2020-10-01

Model‐Based Analysis Reveals a Sustained and Dose‐Dependent Acceleration of Wound Healing by VEGF‐A mRNA (AZD8601)

by Joachim Almquist, S. Michaela Rikard, Maria Wågberg, Anthony C. Bruce, Peter Gennemark, Regina Fritsche‐Danielson, Kenneth R. Chien, Shayn M. Peirce, Kenny Hansson, Anna Lundahl
Published 2020-07-01

Efficient Pharmacokinetic Modeling Workflow With the MonolixSuite: A Case Study of Remifentanil

by Pauline Traynard, Géraldine Ayral, Monika Twarogowska, Jonathan Chauvin
Published 2020-04-01

Phase II Dose Selection for Alpha Synuclein–Targeting Antibody Cinpanemab (BIIB054) Based on Target Protein Binding Levels in the Brain

by Mita Kuchimanchi, Michael Monine, Kumar Kandadi Muralidharan, Caroline Woodward, Natalia Penner
Published 2020-09-01

Prediction of the Pharmacokinetics of Pravastatin as an OATP Substrate Using Plateable Human Hepatocytes With Human Plasma Data and PBPK Modeling

by Jialin Mao, Utkarsh Doshi, Matthew Wright, Cornelis E. C. A. Hop, Albert P. Li, Yuan Chen
Published 2018-04-01

CORRIGENDUM: Quantitative Systems Pharmacology Model of hUGT1A1‐modRNA Encoding for the UGT1A1 Enzyme to Treat Crigler‐Najjar Syndrome Type 1

by J.F. Apgar, J.P. Tang, P. Singh, N. Balasubramanian, J.M. Burke, M.R. Hodges, M.A. Lasaro, L. Lin, B.L. Millard, K. Moore, L.S. Jun, S. Sobolov, A.K. Wilkins, X. Gao
Published 2020-03-01

gQSPSim: A SimBiology‐Based GUI for Standardized QSP Model Development and Application

by Iraj Hosseini, Justin Feigelman, Anita Gajjala, Monica Susilo, Vidya Ramakrishnan, Saroja Ramanujan, Kapil Gadkar
Published 2020-03-01

A New Method to Model and Predict Progression Free Survival Based on Tumor Growth Dynamics

by Jiajie Yu, Nina Wang, Matts Kågedal
Published 2020-03-01

Kinetic‐Pharmacodynamic Model of Platelet Time Course in Patients With Moderate‐to‐Severe Atopic Dermatitis Treated With Oral Janus Kinase 1 Inhibitor Abrocitinib

by Elena Soto, Christopher Banfield, Pankaj Gupta, Mark C. Peterson
Published 2020-10-01

Response Letter to the Editor: “Assumption Checking Before Application of the Prespecified QT Linear Mixed Effect Model is Essential”

by Yeamin Huh, Steve Riley, Timothy Nicholas
Published 2020-07-01

Assumption Checking Before Application of the Prespecified QT Linear Mixed Effect Model is Essential

by Dinko Rekić, Joanna Parkinson, Holly Kimko
Published 2020-07-01

Quantitative Systems Pharmacology and Physiologically‐Based Pharmacokinetic Modeling With mrgsolve: A Hands‐On Tutorial

by Ahmed Elmokadem, Matthew M. Riggs, Kyle T. Baron
Published 2019-12-01

Population Pharmacokinetics of Nivolumab in Combination With Ipilimumab in Patients With Advanced Malignancies

by Jason Zhang, Kinjal Sanghavi, Jun Shen, Xiaochen Zhao, Yan Feng, Paul Statkevich, Jennifer Sheng, Amit Roy, Li Zhu
Published 2019-12-01

Pharmacokinetics of Capecitabine and Four Metabolites in a Heterogeneous Population of Cancer Patients: A Comprehensive Analysis

by Bart A.W. Jacobs, Maarten J. Deenen, Markus Joerger, Hilde Rosing, Niels deVries, Didier Meulendijks, Annemieke Cats, Jos H. Beijnen, Jan H.M. Schellens, Alwin D.R. Huitema
Published 2019-12-01

What “Impact” Do NLME Publications Have Outside Our Community?

by Stefanie Hennig, Julia Fischer, Charlotte Kloft
Published 2020-04-01

Population Pharmacokinetics and Exposure–Response of Luspatercept, an Erythroid Maturation Agent, in Anemic Patients With Myelodysplastic Syndromes

by Nianhang Chen, Nastya Kassir, Abderrahmane Laadem, Stephen E. Maxwell, Priya Sriraman, Ana Carolina Giuseppi, Steve Ritland, Peter G. Linde, Balasubrahmanyam Budda, Joseph G. Reynolds, Simon Zhou, Maria Palmisano
Published 2020-07-01

The Risk of Treating Populations Instead of Patients

by Amelia N. Deitchman
Published 2019-05-01

Nonlinear Mixed‐Effects Model Development and Simulation Using nlmixr and Related R Open‐Source Packages

by Matthew Fidler, Justin J. Wilkins, Richard Hooijmaijers, Teun M. Post, Rik Schoemaker, Mirjam N. Trame, Yuan Xiong, Wenping Wang
Published 2019-09-01