CRISPR-CAS9 system 13 Article 10 nonhuman 10 controlled study 8 gene editing 8 genetics 7 CRISPR Cas system 6 CRISPR-Cas Systems 6 Animals 5 CRISPR/Cas9 5 animal 5 gene mutation 5 human 5 Gene Editing 4 Humans 4 gene expression 4 protein expression 4 Mice 3 Sanger sequencing 3 Western blotting 3 article 3 clustered regularly interspaced short palindromic repeat 3 gene sequence 3 genetic transcription 3 mouse 3 plasmid 3 polymerase chain reaction 3 protein function 3 CRISPR associated endonuclease Cas9 2 CRISPR-Cas9 2