Radiosensitizing activity of novel small molecule BRCA1 and DNA-PK inhibitors in lung and colon carcinoma

by Suraj Radhamani, Ph.D, Rejitha Suraj, Ph.D, Terri Meehan-Andrews, Ph.D, Jasim Al-Rawi, Christopher Bradley, Ph.D
Published 2017-07-01

Blockade of Radiation-induced EGFR Nuclear Transport Enhances Radiosensitivity of Human Cervical Cancer

by LI Lu, HUANG Jianming, FENG Mei, QI Yunxiang, MA Shiqi, TAN Mingyu, LANG Jinyi
Published 2020-01-01

DNA-Sensing Antiviral Innate Immunity in Poxvirus Infection

by Yue Lu, Yue Lu, Yue Lu, Yue Lu, Leiliang Zhang, Leiliang Zhang, Leiliang Zhang, Leiliang Zhang, Leiliang Zhang
Published 2020-08-01

Co-Inhibition of the DNA Damage Response and CHK1 Enhances Apoptosis of Neuroblastoma Cells

by Kiyohiro Ando, Yohko Nakamura, Hiroki Nagase, Akira Nakagawara, Tsugumichi Koshinaga, Satoshi Wada, Makoto Makishima
Published 2019-07-01

Etoposide Triggers Cellular Senescence by Inducing Multiple Centrosomes and Primary Cilia in Adrenocortical Tumor Cells

by Yen-Ni Teng, Huei-Cih Chang, Yu-Ying Chao, Hui-Ling Cheng, Wei-Chih Lien, Chia-Yih Wang
Published 2021-06-01

The Role of DNA Repair Complex DNA-PK in HIV-1 Transcription

by Olga Shadrina, Andrey Anisenko, Marina Gottikh
Published 2020-07-01

Increased Non-Homologous End Joining Makes DNA-PK a Promising Target for Therapeutic Intervention in Uveal Melanoma

by Rachel E. Doherty, Helen E. Bryant, Manoj K. Valluru, Ian G. Rennie, Karen Sisley
Published 2019-08-01

DNA-PK as an Emerging Therapeutic Target in Cancer

by Ismail S. Mohiuddin, Min H. Kang
Published 2019-07-01

Chemical inhibition of DNA repair kinases as a promising tool in oncology

by Kamila Durisova, Barbora Salovska, Jaroslav Pejchal, Ales Tichy
Published 2016-03-01

DNA–dependent protein kinase in telomere maintenance and protection

by Jiangdong Sui, Shichuan Zhang, Benjamin P. C. Chen
Published 2020-01-01

DNA-PK is a DNA sensor for IRF-3-dependent innate immunity

by Brian J Ferguson, Daniel S Mansur, Nicholas E Peters, Hongwei Ren, Geoffrey L Smith
Published 2012-12-01

MTA1 Promotes Hepatocellular Carcinoma Progression by Downregulation of DNA-PK-Mediated H1.2T146 Phosphorylation

by Yu-Hui Li, Ming Zhong, Hong-Liang Zang, Xiao-Feng Tian
Published 2020-05-01

Small molecules, inhibitors of DNA-PK, targeting DNA repair and beyond

by David eDavidson, Lilian eAmrein, Lawrence ePanasci, Raquel eAloyz
Published 2013-01-01

The role of DNA-dependent protein kinase in tumor metastasis

by Kotula, Ewa
Published 2014

RESOLUTION OF PROXIMAL OXIDATIVE BASE DAMAGE AND 3′-PHOSPHATE TERMINI FOR NONHOMOLOGOUS END JOINING OF FREE RADICAL-MEDIATED DNA DOUBLE-STRAND BREAKS

by Chalasani, Sri Lakshmi
Published 2018

Reactivation of heat-inactivated Ku proteins by heat shock cognate protein HSC73

by Makoto Ihara, Kazuko Shichijo, Takashi Kudo, Kenzo Ohtsuka
Published 2019-01-01

Differential Expression of DNA Repair Genes in Prognostically-Favorable versus Unfavorable Uveal Melanoma

by Mehmet Dogrusöz, Andrea Ruschel Trasel, Jinfeng Cao, Selҫuk Ҫolak, Sake I. van Pelt, Wilma G. M. Kroes, Amina F. A. S. Teunisse, Samar Alsafadi, Sjoerd G. van Duinen, Gregorius P. M. Luyten, Pieter A. van der Velden, Adriana Amaro, Ulrich Pfeffer, Aart G. Jochemsen, Martine J. Jager
Published 2019-08-01

NU7441 Enhances the Radiosensitivity of Liver Cancer Cells

by Chuanjie Yang, Quanxu Wang, Xiaodan Liu, Xiulian Cheng, Xiaoyu Jiang, Yuan Zhang, Zhijie Feng, Pingkun Zhou
Published 2016-05-01

Overcoming hypoxia-induced tumor radioresistance in non-small cell lung cancer by targeting DNA-dependent protein kinase in combination with carbon ion irradiation

by Carmen Klein, Ivana Dokic, Andrea Mairani, Stewart Mein, Stephan Brons, Peter Häring, Thomas Haberer, Oliver Jäkel, Astrid Zimmermann, Frank Zenke, Andree Blaukat, Jürgen Debus, Amir Abdollahi
Published 2017-12-01

Commentary: High Expression of Cancer-IgG Is Associated With Poor Prognosis and Radioresistance via PI3K/AKT/DNA-PKcs Pathway Regulation in Lung Adenocarcinoma

by Liu Yang, Pingan Lu, Song Qu, Song Qu
Published 2021-10-01