controlled study human 180 Article 161 Humans 151 female 140 male 134 adult 116 major clinical study 112 Female 94 Male 87 middle aged 79 Middle Aged 66 sensitivity and specificity 65 aged 59 diagnostic test accuracy study 57 Adult 48 procedures 48 diagnosis 46 receiver operating characteristic 45 diagnostic imaging 41 Aged 37 blood 37 pathology 37 genetics 35 Diagnosis 32 diagnostic value 31 clinical article 30 retrospective study 29 cancer diagnosis 28 early diagnosis 27