adult human 99 female 85 male 85 Humans 76 Article 64 Male 59 controlled study 58 Female 57 Adult 54 middle aged 54 Middle Aged 50 age distribution 45 aged 45 major clinical study 45 young adult 34 Aged 32 Young Adult 31 sex difference 27 Adolescent 23 adolescent 23 article 19 prevalence 18 retrospective study 16 age 15 cohort analysis 15 cross-sectional study 15 risk factor 15 body mass 14 questionnaire 14