Co-trimoxazole to reduce mortality, transplant, or unplanned hospitalisation in people with moderate to very severe idiopathic pulmonary fibrosis: the EME-TIPAC RCT

by Andrew M Wilson, Allan B Clark, Anthony Cahn, Edwin R Chilvers, William Fraser, Matthew Hammond, David M Livermore, Toby M Maher, Helen Parfrey, Ann Marie Swart, Susan Stirling, David Thickett, Moira Whyte
Published 2021-07-01

Defining phenotypes and treatment effect heterogeneity to inform acute respiratory distress syndrome and sepsis trials: secondary analyses of three RCTs

by Manu Shankar-Hari, Shalini Santhakumaran, A Toby Prevost, Josie K Ward, Timothy Marshall, Claire Bradley, Carolyn S Calfee, Kevin L Delucchi, Pratik Sinha, Michael A Matthay, Jonathan Hackett, Cliona McDowell, John G Laffey, Anthony Gordon, Cecilia M O’Kane, Daniel F McAuley
Published 2021-07-01

Emergent aneurysm treatment compared with treatment on neurological improvement in patients with ruptured poor-grade aneurysmal subarachnoid haemorrhage: the TOPSAT2 RCT

by Philip White, Barbara Gregson, Elaine McColl, Paul Brennan, Alison Steel, Philippa Watts, Ruth Wood, Clare Bowes, Mohsen Javadpour, Amanda Weston, Dipayan Mitra
Published 2021-07-01

Digitally supported CBT to reduce paranoia and improve reasoning for people with schizophrenia-spectrum psychosis: the SlowMo RCT

by Philippa Garety, Thomas Ward, Richard Emsley, Kathryn Greenwood, Daniel Freeman, David Fowler, Elizabeth Kuipers, Paul Bebbington, Graham Dunn, Amy Hardy
Published 2021-08-01

Probiotics to reduce antibiotic administration in care home residents aged 65 years and older: the PRINCESS RCT

by Christopher C Butler, Eleri Owen-Jones, Mandy Lau, David Gillespie, Mark Lown, Philip C Calder, Helen Stanton, Mandy Wootton, Vivian Castro Herrera, Antony Bayer, Jane Davies, Alison Edwards, Mina Davoudianfar, Heather Rutter, Kerenza Hood, Michael Moore, Paul Little, Victoria Shepherd, Rachel Lowe, Elizabeth A Miles, Julia Townson, FD Richard Hobbs, Nick A Francis
Published 2021-04-01

Long limb compared with standard limb Roux-en-Y gastric bypass for type 2 diabetes and obesity: the LONG LIMB RCT

by Alexander Dimitri Miras, Anna Kamocka, Tricia Tan, Belén Pérez-Pevida, Harvinder Chahal, Krishna Moorthy, Sanjay Purkayastha, Ameet Patel, Anne Margot Umpleby, Gary Frost, Stephen Robert Bloom, Ahmed Rashid Ahmed, Francesco Rubino
Published 2021-02-01

Eplerenone versus placebo for chronic central serous chorioretinopathy: the VICI RCT

by Andrew Lotery, Sobha Sivaprasad, Abby O’Connell, Rosie A Harris, Lucy Culliford, Angela Cree, Savita Madhusudhan, Helen Griffiths, Lucy Ellis, Usha Chakravarthy, Tunde Peto, Chris A Rogers, Barnaby C Reeves
Published 2021-01-01

Low-dose intracoronary alteplase during primary percutaneous coronary intervention in patients with acute myocardial infarction: the T-TIME three-arm RCT

by Peter J McCartney, Hany Eteiba, Annette M Maznyczka, Margaret McEntegart, John P Greenwood, Douglas F Muir, Saqib Chowdhary, Anthony H Gershlick, Clare Appleby, James M Cotton, Andrew Wragg, Nick Curzen, Keith G Oldroyd, Mitchell Lindsay, J Paul Rocchiccioli, Aadil Shaukat, Richard Good, Stuart Watkins, Keith Robertson, Christopher Malkin, Lynn Martin, Lynsey Gillespie, Thomas J Ford, Mark C Petrie, Peter W Macfarlane, R Campbell Tait, Paul Welsh, Naveed Sattar, Robin A Weir, Keith A Fox, Ian Ford, Alex McConnachie, Colin Berry
Published 2020-11-01

Gabapentin to reduce pain in women aged between 18 and 50 years with chronic pelvic pain: the GaPP2 RCT

by Catherine A Hewitt, Katy Vincent, Lee J Middleton, Liana Romaniuk, Magda Koscielniak, Ann M Doust, Judy Birch, Heather Whalley, Jane P Daniels, Andrew W Horne
Published 2020-11-01

Stratifying risk of infection and response to therapy in patients with myeloma: a prognostic study

by Ilaria J Chicca, Jennifer LJ Heaney, Gulnaz Iqbal, Janet A Dunn, Stella Bowcock, Tim Planche, Guy Pratt, Kwee Yong, Eric Low, Jill Wood, Kerry Raynes, Helen Higgins, Mark T Drayson
Published 2020-12-01

A duodenal sleeve bypass device added to intensive medical therapy for obesity with type 2 diabetes: a RCT

by Aruchuna Ruban, Michael A Glaysher, Alexander D Miras, Anthony P Goldstone, Christina G Prechtl, Nicholas Johnson, Jia Li, Madhawi Aldhwayan, Ghadah Aldubaikhi, Ben Glover, Joanne Lord, Olu Onyimadu, Emmanuela Falaschetti, Natalia Klimowska-Nassar, Hutan Ashrafian, James Byrne, Julian P Teare
Published 2020-11-01

Ursodeoxycholic acid to reduce adverse perinatal outcomes for intrahepatic cholestasis of pregnancy: the PITCHES RCT

by Lucy C Chappell, Jennifer L Bell, Anne Smith, Catherine Rounding, Ursula Bowler, Louise Linsell, Edmund Juszczak, Sue Tohill, Amanda Redford, Peter H Dixon, Jenny Chambers, Rachael Hunter, Jon Dorling, Catherine Williamson, Jim G Thornton
Published 2020-12-01

Mini-combined test compared with NICE guidelines for early risk-assessment for pre-eclampsia: the SPREE diagnostic accuracy study

by Liona C Poon, David Wright, Steve Thornton, Ranjit Akolekar, Peter Brocklehurst, Kypros H Nicolaides
Published 2020-11-01

Enhanced neoplasia detection in chronic ulcerative colitis: the ENDCaP-C diagnostic accuracy study

by Ashish Awasthi, Jamie Barbour, Andrew Beggs, Pradeep Bhandari, Daniel Blakeway, Matthew Brookes, James Brown, Matthew Brown, Germaine Caldwell, Samuel Clokie, Ben Colleypriest, Abby Conlin, Shanika de Silva, John de Caestecker, Jonathan Deeks, Anjan Dhar, Mark Dilworth, Edward Fogden, Stephen Foley, Deb Ghosh, Leonie Grellier, Ailsa Hart, Syed Samiul Hoque, Marietta Iacucci, Tariq Iqbal, Jonathan James, Mark Jarvis, Anthoor Jayaprakash, Satish Keshav, Laura Magill, Glenn Matthews, Joel Mawdsley, Simon McLaughlin, Samir Mehta, Kevin Monahan, Dion Morton, Senthil Murugesan, Miles Parkes, Valerie Pestinger, Chris Probert, Arvind Ramadas, Alessandro Rettino, Shaji Sebastian, Naveen Sharma, Michael Griffiths, Joanne Stockton, Venkat Subramanian, Nigel Suggett, Philippe Taniere, Julian Teare, Ajay M Verma, Yvonne Wallis
Published 2021-01-01

Efficacy and mode of action of mesalazine in the treatment of diarrhoea-predominant irritable bowel syndrome (IBS-D): a multicentre, parallel-group, randomised placebo-controlled t...

by Ching Lam, Wei Tan, Matthew Leighton, Margaret Hastings, Melanie Lingaya, Yirga Falcone, Xiaoying Zhou, Luting Xu, Peter Whorwell, Andrew F Walls, Abed Zaitoun, Alan Montgomery, Robin C Spiller
Published 2015-03-01

REmote preconditioning for Protection Against Ischaemia–Reperfusion in renal transplantation (REPAIR): a multicentre, multinational, double-blind, factorial designed randomised con...

by Raymond MacAllister, Tim Clayton, Rosemary Knight, Steven Robertson, Jennifer Nicholas, Madhur Motwani, Kristin Veighey
Published 2015-05-01

Study of induction of Tolerance to Oral Peanut: a randomised controlled trial of desensitisation using peanut oral immunotherapy in children (STOP II)

by Katherine Anagnostou, Sabita Islam, Yvonne King, Loraine Foley, Laura Pasea, Chris Palmer, Simon Bond, Pamela Ewan, Andrew Clark
Published 2014-12-01

Developing and applying a framework to understand mechanisms of action in group-based, behaviour change interventions: the MAGI mixed-methods study

by Aleksandra J Borek, Jane R Smith, Colin J Greaves, Fiona Gillison, Mark Tarrant, Sarah Morgan-Trimmer, Rose McCabe, Charles Abraham
Published 2019-06-01

Amiloride, fluoxetine or riluzole to reduce brain volume loss in secondary progressive multiple sclerosis: the MS-SMART four-arm RCT

by Floriana De Angelis, Peter Connick, Richard A Parker, Domenico Plantone, Anisha Doshi, Nevin John, Jonathan Stutters, David MacManus, Ferran Prados, Ian Marshall, Bhavana Solanky, Rebecca S Samson, Frederik Barkhof, Sebastien Ourselin, Marie Braisher, Moira Ross, Gina Cranswick, Sue H Pavitt, Sharmilee Gnanapavan, Gavin Giovannoni, Claudia AM Gandini Wheeler-Kingshott, Clive Hawkins, Basil Sharrack, Roger Bastow, Christopher J Weir, Nigel Stallard, Siddharthan Chandran, Jeremy Chataway
Published 2020-05-01

Spironolactone to improve exercise tolerance in people with permanent atrial fibrillation and preserved ejection fraction: the IMPRESS-AF RCT

by Eduard Shantsila, Farhan Shahid, Yongzhong Sun, Jonathan J Deeks, Ronnie Haynes, Melanie Calvert, James P Fisher, Paulus Kirchhof, Paramjit S Gill, Gregory YH Lip
Published 2020-07-01