Therapeutic Peptides Targeting PPI in Clinical Development: Overview, Mechanism of Action and Perspectives

by Walter Cabri, Paolo Cantelmi, Dario Corbisiero, Tommaso Fantoni, Lucia Ferrazzano, Giulia Martelli, Alexia Mattellone, Alessandra Tolomelli
Published 2021-06-01

Gremlin2 Activates Fibroblasts to Promote Pulmonary Fibrosis Through the Bone Morphogenic Protein Pathway

by Caijuan Huan, Wangting Xu, Yaru Liu, Kexin Ruan, Yueli Shi, Hongqiang Cheng, Xue Zhang, Yuehai Ke, Jianying Zhou
Published 2021-06-01

A Minireview of the Promising Drugs and Vaccines in Pipeline for the Treatment of COVID-19 and Current Update on Clinical Trials

by Jeyanthi Venkadapathi, Venkat Kumar Govindarajan, Saravanan Sekaran, Santhi Venkatapathy
Published 2021-06-01

Lipid Metabolism Regulates Oxidative Stress and Ferroptosis in RAS-Driven Cancers: A Perspective on Cancer Progression and Therapy

by Caterina Bartolacci, Cristina Andreani, Yasmin El-Gammal, Pier Paolo Scaglioni
Published 2021-08-01

RUNX1 Upregulates CENPE to Promote Leukemic Cell Proliferation

by Shan Liu, Shan Liu, Jianyu Yang, Guohuan Sun, Yawen Zhang, Cong Cheng, Cong Cheng, Jin Xu, Kuangyu Yen, Ting Lu
Published 2021-08-01

Exploring Covalent Docking Mechanisms of Boron-Based Inhibitors to Class A, C and D β-Lactamases Using Time-dependent Hybrid QM/MM Simulations

by Łukasz Charzewski, Krystiana A. Krzyśko, Bogdan Lesyng
Published 2021-08-01

ADAMTS5 in Osteoarthritis: Biological Functions, Regulatory Network, and Potential Targeting Therapies

by Lejian Jiang, Lejian Jiang, Jiachen Lin, Jiachen Lin, Jiachen Lin, Sen Zhao, Sen Zhao, Sen Zhao, Jiaqian Wu, Yongming Jin, Li Yu, Nan Wu, Nan Wu, Nan Wu, Zhihong Wu, Zhihong Wu, Zhihong Wu, Yue Wang, Yue Wang, Mao Lin, Mao Lin, Mao Lin, Mao Lin
Published 2021-08-01

Evolving Perspectives on Innate Immune Mechanisms of IPF

by Genta Ishikawa, Angela Liu, Erica L. Herzog, Erica L. Herzog
Published 2021-08-01

Simulating PIP2-Induced Gating Transitions in Kir6.2 Channels

by Michael Bründl, Sarala Pellikan, Anna Stary-Weinzinger
Published 2021-08-01

Cold-Induced RNA-Binding Protein Promotes Glucose Metabolism and Reduces Apoptosis by Increasing AKT Phosphorylation in Mouse Skeletal Muscle Under Acute Cold Exposure

by Yang Liu, Peng Liu, Yajie Hu, Yu Cao, Jingjing Lu, Yuying Yang, Hongming Lv, Shuai Lian, Bin Xu, Shize Li
Published 2021-07-01

Comprehensive Metabolic Signature of Renal Dysplasia in Children. A Multiplatform Metabolomics Concept

by Szymon Macioszek, Renata Wawrzyniak, Anna Kranz, Marta Kordalewska, Wiktoria Struck-Lewicka, Danuta Dudzik, Margot Biesemans, Michał Maternik, Aleksandra M. Żurowska, Michał J. Markuszewski
Published 2021-07-01

Dissecting Metabolism of Leaf Nodules in Ardisia crenata and Psychotria punctata

by Florian Schindler, Lena Fragner, Lena Fragner, Johannes B. Herpell, Andreas Berger, Martin Brenner, Martin Brenner, Martin Brenner, Sonja Tischler, Sonja Tischler, Anke Bellaire, Jürg Schönenberger, Weimin Li, Xiaoliang Sun, Johann Schinnerl, Lothar Brecker, Wolfram Weckwerth, Wolfram Weckwerth
Published 2021-07-01

RNA Polymerase III Subunit Mutations in Genetic Diseases

by Elisabeth Lata, Karine Choquet, Francis Sagliocco, Bernard Brais, Geneviève Bernard, Geneviève Bernard, Geneviève Bernard, Martin Teichmann
Published 2021-07-01

Identification of a Gene Set Correlated With Immune Status in Ovarian Cancer by Transcriptome-Wide Data Mining

by Lili Fan, Lili Fan, Han Lei, Ying Lin, Zhengwei Zhou, Guang Shu, Zhipeng Yan, Haotian Chen, Tianxiang Zhang, Gang Yin
Published 2021-07-01

Deciphering the Oncogenic Role of VPS28 Modulated by miR-491-5p in Breast Cancer Cells Using In Silico and Functional Analysis

by Wenjie Shi, Daojun Hu, Yu Xing, Rui Zhuo, Qiufeng Lao, Hui Liu, Weiyi Pang
Published 2021-07-01

Editorial: Computational Solutions for Microbiome and Metagenomics Sequencing Analyses

by Md. Selim Reza, Md. Selim Reza, YunPeng Cai, Lu Zhang, Xingyu Zhang, Yanjie Wei, Yanjie Wei
Published 2021-07-01

Prognostic Prediction, Immune Microenvironment, and Drug Resistance Value of Collagen Type I Alpha 1 Chain: From Gastrointestinal Cancers to Pan-Cancer Analysis

by Yi Liu, Yi Liu, Yi Liu, Jinmin Xue, Jinmin Xue, Jinmin Xue, Maoxi Zhong, Maoxi Zhong, Maoxi Zhong, Zhi Wang, Zhi Wang, Zhi Wang, Jie Li, Jie Li, Jie Li, Yuxi Zhu, Yuxi Zhu, Yuxi Zhu
Published 2021-07-01

Ferroptosis-Related Gene Signature and Patterns of Immune Infiltration Predict the Overall Survival in Patients With Lung Adenocarcinoma

by Yuxuan Wang, Yuxuan Wang, Weikang Chen, Weikang Chen, Minqi Zhu, Minqi Zhu, Lei Xian, Lei Xian
Published 2021-07-01

Free Triiodothyronine Connected With Metabolic Changes in Patients With Coronary Artery Disease by Interacting With Other Functional Indicators

by Xiao-xue Tian, Xiao-xue Tian, Xiao-xue Tian, Shu-fen Zheng, Shu-fen Zheng, Shu-fen Zheng, Ju-e Liu, Ju-e Liu, Yuan-yuan Wu, Yuan-yuan Wu, Lu Lin, Lu Lin, Hong-mei Chen, Hong-mei Chen, Li-wen Li, Li-wen Li, Min Qin, Min Qin, Zi-xian Wang, Zi-xian Wang, Qian Zhu, Qian Zhu, Wei-hua Lai, Shilong Zhong, Shilong Zhong, Shilong Zhong, Shilong Zhong
Published 2021-07-01

p53–GSDME Elevation: A Path for CDK7 Inhibition to Suppress Breast Cancer Cell Survival

by Yueyuan Wang, Jingyu Peng, Xuguang Mi, Ming Yang
Published 2021-08-01