Inhibitory effects of flavonoids isolated from Sophora flavescens on indoleamine 2,3-dioxygenase 1 activity

by Mincheol Kwon, Sung-Kyun Ko, Mina Jang, Gun-Hee Kim, In-Ja Ryoo, Sangkeun Son, Hyung Won Ryu, Sei-Ryang Oh, Won-Kyu Lee, Bo Yeon Kim, Jae-Hyuk Jang, Jong Seog Ahn
Published 2019-01-01

A highly potent and selective inhibitor Roxyl-WL targeting IDO1 promotes immune response against melanoma

by Guangwei Xu, Tianqi Wang, Yongtao Li, Zhi Huang, Xin Wang, Jianyu Zheng, Shengyong Yang, Yan Fan, Rong Xiang
Published 2018-01-01

Ativação supraespinal da via das quinureninas contribui para a manutenção da dor neuropática

by Dênis Augusto Santana Reis
Published 2015

Ativação supraespinal da via das quinureninas contribui para a manutenção da dor neuropática

by Reis, Dênis Augusto Santana
Published 2015

The Clinicopathological and Prognostic Significance of IDO1 Expression in Human Solid Tumors: Evidence from a Systematic Review and Meta-Analysis

by Cheng-Peng Yu, Shu-Fang Fu, Xuan Chen, Jing Ye, Yuan Ye, Ling-Dong Kong, Zhengming Zhu
Published 2018-08-01

Tryptophan: A Rheostat of Cancer Immune Escape Mediated by Immunosuppressive Enzymes IDO1 and TDO

by Minah Kim, Petr Tomek
Published 2021-02-01

Phase Ia study of the indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor navoximod (GDC-0919) in patients with recurrent advanced solid tumors

by Asha Nayak-Kapoor, Zhonglin Hao, Ramses Sadek, Robin Dobbins, Lisa Marshall, Nicholas N. Vahanian, W. Jay Ramsey, Eugene Kennedy, Mario R. Mautino, Charles J. Link, Ray S. Lin, Stephanie Royer-Joo, Xiaorong Liang, Laurent Salphati, Kari M. Morrissey, Sami Mahrus, Bruce McCall, Andrea Pirzkall, David H. Munn, John E. Janik, Samir N. Khleif
Published 2018-06-01

IL4I1 Is Expressed by Head–Neck Cancer-Derived Mesenchymal Stromal Cells and Contributes to Suppress T Cell Proliferation

by Alessio Mazzoni, Manuela Capone, Matteo Ramazzotti, Anna Vanni, Luca Giovanni Locatello, Oreste Gallo, Raffaele De Palma, Lorenzo Cosmi, Francesco Liotta, Francesco Annunziato, Laura Maggi
Published 2021-05-01

Inhibition of Tryptophan Catabolism Is Associated With Neuroprotection During Zika Virus Infection

by Fernanda Martins Marim, Fernanda Martins Marim, Fernanda Martins Marim, Danielle Cunha Teixeira, Danielle Cunha Teixeira, Celso Martins Queiroz-Junior, Celso Martins Queiroz-Junior, Celso Martins Queiroz-Junior, Bruno Vinicius Santos Valiate, Bruno Vinicius Santos Valiate, Jose Carlos Alves-Filho, Thiago Mattar Cunha, Robert Dantzer, Mauro Martins Teixeira, Mauro Martins Teixeira, Mauro Martins Teixeira, Antonio Lucio Teixeira, Vivian Vasconcelos Costa, Vivian Vasconcelos Costa, Vivian Vasconcelos Costa
Published 2021-07-01

Indoleamine-2,3-Dioxygenase 1 Deficiency Suppresses Seizures in Epilepsy

by Ning Deng, Jiao Hu, Yu Hong, Yu Hong, Yuewen Ding, Yuewen Ding, Yifan Xiong, Zhiyong Wu, Zhiyong Wu, Wei Xie, Wei Xie
Published 2021-02-01

IDO1 Expression Increased After Neoadjuvant Therapy Predicts Poor Pathologic Response and Prognosis in Esophageal Squamous Cell Carcinoma

by Ruidi Jiao, Xiaoli Zheng, Yanan Sun, Zhuo Feng, Shuai Song, Hong Ge
Published 2020-07-01

Carboxyamidotriazole combined with IDO1-Kyn-AhR pathway inhibitors profoundly enhances cancer immunotherapy

by Jing Shi, Chen Chen, Rui Ju, Qingzhu Wang, Juan Li, Lei Guo, Caiying Ye, Dechang Zhang
Published 2019-09-01

Phase 1/2 study of epacadostat in combination with ipilimumab in patients with unresectable or metastatic melanoma

by Geoffrey T. Gibney, Omid Hamid, Jose Lutzky, Anthony J. Olszanski, Tara C. Mitchell, Thomas F. Gajewski, Bartosz Chmielowski, Brent A. Hanks, Yufan Zhao, Robert C. Newton, Janet Maleski, Lance Leopold, Jeffrey S. Weber
Published 2019-03-01

Imprinted and ancient gene: a potential mediator of cancer cell survival during tryptophan deprivation

by Petr Tomek, Shanti K. Gore, Chloe L. Potts, Cristin G. Print, Michael A. Black, Ariane Hallermayr, Michael Kilian, Evelyn Sattlegger, Lai-Ming Ching
Published 2018-11-01

Inhibition of indoleamine 2,3-dioxygenase 1 synergizes with oxaliplatin for efficient colorectal cancer therapy

by Xiaofei Miao, Ye Zhang, Zengyao Li, Longchang Huang, Taojian Xin, Renhui Shen, Tong Wang
Published 2021-03-01

The Role of the Kynurenine Signaling Pathway in Different Chronic Pain Conditions and Potential Use of Therapeutic Agents

by Filip Jovanovic, Kenneth D. Candido, Nebojsa Nick Knezevic
Published 2020-08-01

Toxoplasma Effector GRA15-Dependent Suppression of IFN-γ-Induced Antiparasitic Response in Human Neurons

by Hironori Bando, Hironori Bando, Youngae Lee, Youngae Lee, Naoya Sakaguchi, Ariel Pradipta, Ryoma Sakamoto, Shun Tanaka, Ji Su Ma, Ji Su Ma, Miwa Sasai, Miwa Sasai, Masahiro Yamamoto, Masahiro Yamamoto
Published 2019-05-01

Discovery of Novel Indoleamine 2,3-Dioxygenase 1 (IDO1) and Histone Deacetylase 1 (HDAC1) Dual Inhibitors Derived from the Natural Product Saprorthoquinone

by Yang Lin, Heyanhao Zhang, Tong Niu, Mei-Lin Tang, Jun Chang
Published 2020-09-01

Influence of the tryptophan-indole-IFNγ axis on human genital Chlamydia trachomatis infection: role of vaginal co-infections

by Ashok eAiyar, Alison J. Quayle, Lyndsey B. Buckner, Shardulendra P. Sherchand, Theresa L. Chang, Arnold H. Zea, David H. Martin, Robert J. Belland
Published 2014-06-01

Tumor endothelial cell up-regulation of IDO1 is an immunosuppressive feed-back mechanism that reduces the response to CD40-stimulating immunotherapy

by Maria Georganaki, Mohanraj Ramachandran, Sander Tuit, Nicolás Gonzalo Núñez, Alexandros Karampatzakis, Grammatiki Fotaki, Luuk van Hooren, Hua Huang, Roberta Lugano, Thomas Ulas, Aura Kaunisto, Eric C Holland, Peter Ellmark, Sara M Mangsbo, Joachim Schultze, Magnus Essand, Sonia Tugues, Anna Dimberg
Published 2020-01-01