animal experiment 39 animal model nonhuman 39 controlled study 37 Article 36 Animals 27 animal 26 animal tissue 26 male 26 mouse 26 interleukin 6 23 metabolism 21 interleukin 1beta 17 tumor necrosis factor 17 female 16 Mice 15 animal cell 15 protein expression 14 inflammation 13 Cytokines 12 Male 12 gamma interferon 12 human 12 Disease Models, Animal 11 Humans 11 cytokine 11 disease model 11 rat 11 unclassified drug 11 Western blotting 9