metabolism human 67 Humans 65 Article 53 controlled study 47 interleukin 6 46 male 41 Animals 35 Male 35 animal 35 cytokine 35 female 35 tumor necrosis factor 35 Cytokines 34 interleukin 1beta 32 nonhuman 32 Female 31 genetics 28 pathology 28 animal experiment 23 drug effect 23 mouse 23 Mice 22 protein expression 22 unclassified drug 22 animal model 21 adult 20 immunology 20 Inflammation 19 biological marker 19