Synthesis, biological evaluation, and molecular modelling of new naphthalene-chalcone derivatives as potential anticancer agents on MCF-7 breast cancer cells by targeting tubulin c...

by Guangcheng Wang, Wenjing Liu, Zipeng Gong, Yong Huang, Yongjun Li, Zhiyun Peng
Published 2020-01-01

Novel benzofuran-based sulphonamides as selective carbonic anhydrases IX and XII inhibitors: synthesis and in vitro biological evaluation

by Mohamed A. Abdelrahman, Wagdy M. Eldehna, Alessio Nocentini, Hany S. Ibrahim, Hadia Almahli, Hatem A. Abdel-Aziz, Sahar M. Abou-Seri, Claudiu T. Supuran
Published 2020-01-01

Novel tacrine–benzofuran hybrids as potential multi-target drug candidates for the treatment of Alzheimer’s Disease

by Gaia Fancellu, Karam Chand, Daniel Tomás, Elisabetta Orlandini, Luca Piemontese, Diana F. Silva, Sandra M. Cardoso, Sílvia Chaves, M. Amélia Santos
Published 2020-01-01

Synthesis of thiazolidin-4-ones and thiazinan-4-ones from 1-(2-aminoethyl)pyrrolidine as acetylcholinesterase inhibitors

by Adriana M. das Neves, Gabriele A. Berwaldt, Cinara T. Avila, Taís B. Goulart, Bruna C. Moreira, Taís P. Ferreira, Mayara S. P. Soares, Nathalia S. Pedra, Luiza Spohr, Anita A. A. dE Souza, Roselia M. Spanevello, Wilson Cunico
Published 2020-01-01

Discovery and evaluation of novel synthetic 5-alkyl-4-oxo-4,5-dihydro-[1,2,4]triazolo[4,3-a]quinoxaline-1-carbox-amide derivatives as anti-inflammatory agents

by Qing-Kun Shen, Guo-Hua Gong, Gao- Li, Mei- Jin, Li-Hua Cao, Zhe-Shan Quan
Published 2020-01-01

Design, synthesis, and biological evaluation of 5-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)-1H-Indole-2-Carbohydrazide derivatives: the methuosis inducer 12A as a Novel and selective...

by Jun Wu, Hongyu Hu, Mingtao Ao, Zhenzhen Cui, Xiaoping Zhou, Jingbo Qin, Yafei Guo, Jingwei Chen, Yuhua Xue, Meijuan Fang
Published 2021-01-01

Identification of imidazo[4,5-c]pyridin-2-one derivatives as novel Src family kinase inhibitors against glioblastoma

by Lishun Zhang, Zichao Yang, Huiting Sang, Ying Jiang, Mingfeng Zhou, Chuan Huang, Chunhui Huang, Xiaoyun Wu, Tingting Zhang, Xingmei Zhang, Shanhe Wan, Jiajie Zhang
Published 2021-01-01

DNA topoisomerases as molecular targets for anticancer drugs

by Kamila Buzun, Anna Bielawska, Krzysztof Bielawski, Agnieszka Gornowicz
Published 2020-01-01

Structure-activity relationship of 7-aryl-2-anilino-pyrrolopyrimidines as Mer and Axl tyrosine kinase inhibitors

by Shin Hyuck Chung, Jiwon Park, Jung Wuk Lee, Jiho Song, Danbee Jung, Kyung Hoon Min
Published 2020-01-01

Synthesis and biological evaluation of 3-arylbenzofuranone derivatives as potential anti-Alzheimer’s disease agents

by Jie Yang, Yinling Yun, Yuhang Miao, Jie Sun, Xiaojing Wang
Published 2020-01-01

Synthesis and biological evaluation of novel (E)-N'-benzylidene hydrazides as novel c-Met inhibitors through fragment based virtual screening

by Jing-wei Liang, Shi-long Li, Shan Wang, Wan-qiu Li, Fan-hao Meng
Published 2020-01-01

Antitumor properties of certain spirooxindoles towards hepatocellular carcinoma endowed with antioxidant activity

by Sara T. Al-Rashood, Ahmed R. Hamed, Ghada S. Hassan, Hamad M. Alkahtani, Abdulrahman A. Almehizia, Amal Alharbi, Mohammad M. Al-Sanea, Wagdy M. Eldehna
Published 2020-01-01

LC-QTOF-MS analysis of xanthone content in different parts of Garcinia mangostana and its influence on cholinesterase inhibition

by Kooi Yeong Khaw, Chun Wie Chong, Vikneswaran Murugaiyah
Published 2020-01-01

Cytotoxic substituted indolizines as new colchicine site tubulin polymerisation inhibitors

by Monica-Cornelia Sardaru, Anda Mihaela Craciun, Cristina-Maria Al Matarneh, Isabela Andreea Sandu, Roxana Maria Amarandi, Lacramioara Popovici, Catalina Ionica Ciobanu, Dragos Peptanariu, Mariana Pinteala, Ionel I. Mangalagiu, Ramona Danac
Published 2020-01-01

Discovery of secondary sulphonamides as IDO1 inhibitors with potent antitumour effects in vivo

by Shushan Ge, Haiqing Zhong, Xuewei Ma, Yingbo Zheng, Yi Zou, Fang Wang, Yan Wang, Yue Hu, Yuezhen Li, Wen Liu, Wenjie Guo, Qiang Xu, Yisheng Lai
Published 2020-01-01

Tetralone derivatives are MIF tautomerase inhibitors and attenuate macrophage activation and amplify the hypothermic response in endotoxemic mice

by János Garai, Marcell Krekó, László Őrfi, Péter Balázs Jakus, Zoltán Rumbus, Patrik Kéringer, András Garami, Eszter Vámos, Dominika Kovács, Viola Bagóné Vántus, Balázs Radnai, Tamás Lóránd
Published 2021-01-01

Human carbonic anhydrases and post-translational modifications: a hidden world possibly affecting protein properties and functions

by Anna Di Fiore, Claudiu T. Supuran, Andrea Scaloni, Giuseppina De Simone
Published 2020-01-01

Combining carbonic anhydrase and thioredoxin reductase inhibitory motifs within a single molecule dramatically increases its cytotoxicity

by Mikhail Krasavin, Tatiana Sharonova, Vladimir Sharoyko, Daniil Zhukovsky, Stanislav Kalinin, Raivis Žalubovskis, Tatiana Tennikova, Claudiu T. Supuran
Published 2020-01-01

Identification of novel CDK2 inhibitors by a multistage virtual screening method based on SVM, pharmacophore and docking model

by Jing-Wei Liang, Ming-Yang Wang, Shan Wang, Shi-Long Li, Wan-Qiu Li, Fan-Hao Meng
Published 2020-01-01

Design, synthesis and antifungal activity of threoninamide carbamate derivatives via pharmacophore model

by Xiu-Jiang Du, Xing-Jie Peng, Rui-Qi Zhao, Wei-Guang Zhao, Wei-Li Dong, Xing-Hai Liu
Published 2020-01-01