Inhibiting HMGB1-RAGE axis prevents pro-inflammatory macrophages/microglia polarization and affords neuroprotection after spinal cord injury

by Hong Fan, Hai-Bin Tang, Zhe Chen, Hu-Qing Wang, Lei Zhang, Yu Jiang, Tao Li, Cai-Feng Yang, Xiao-Ya Wang, Xia Li, Sheng-Xi Wu, Gui-Lian Zhang
Published 2020-10-01

Evaluation of neurofilament light chain in the cerebrospinal fluid and blood as a biomarker for neuronal damage in experimental pneumococcal meningitis

by Ngoc Dung Le, Lukas Muri, Denis Grandgirard, Jens Kuhle, David Leppert, Stephen L. Leib
Published 2020-10-01

Immunoregulation of microglial polarization: an unrecognized physiological function of α-synuclein

by Na Li, Tessandra Stewart, Lifu Sheng, Min Shi, Eugene M. Cilento, Yufeng Wu, Jau-Syong Hong, Jing Zhang
Published 2020-09-01

The reduction of XIAP is associated with inflammasome activation in RPE: implications for AMD pathogenesis

by Jiangyuan Gao, Jing Z. Cui, Aikun Wang, Hao Hang Rachel Chen, Alison Fong, Joanne A. Matsubara
Published 2019-08-01

Decreased expression of miR-29 family associated with autoimmune myasthenia gravis

by Mélanie A. Cron, Cloé A. Payet, Odessa-Maud Fayet, Solène Maillard, Frédérique Truffault, Elie Fadel, Julien Guihaire, Sonia Berrih-Aknin, Adrian Liston, Rozen Le Panse
Published 2020-10-01

Aryl hydrocarbon receptor modulates stroke-induced astrogliosis and neurogenesis in the adult mouse brain

by Wan-Ci Chen, Li-Hsin Chang, Shiang-Suo Huang, Yu-Jie Huang, Chun-Lien Chih, Hung-Chih Kuo, Yi-Hsuan Lee, I-Hui Lee
Published 2019-10-01

The effect of insomnia on development of Alzheimer’s disease

by Shaghayegh Sadeghmousavi, Mahsa Eskian, Farzaneh Rahmani, Nima Rezaei
Published 2020-10-01

Resveratrol mediates mechanical allodynia through modulating inflammatory response via the TREM2-autophagy axis in SNI rat model

by Yaping Wang, Yu Shi, Yongquan Huang, Wei Liu, Guiyuan Cai, Shimin Huang, Yanyan Zeng, Siqiang Ren, Hongrui Zhan, Wen Wu
Published 2020-10-01

A small peptide antagonist of the Fas receptor inhibits neuroinflammation and prevents axon degeneration and retinal ganglion cell death in an inducible mouse model of glaucoma

by Anitha Krishnan, Andrew J. Kocab, David N. Zacks, Ann Marshak-Rothstein, Meredith Gregory-Ksander
Published 2019-09-01

NFATc2-dependent epigenetic upregulation of CXCL14 is involved in the development of neuropathic pain induced by paclitaxel

by Meng Liu, Su-Bo Zhang, Yu-Xuan Luo, Yan-Ling Yang, Xiang-Zhong Zhang, Bo Li, Yan Meng, Yuan-Jie Chen, Rui-Xian Guo, Yuan-Chang Xiong, Wen-Jun Xin, Dai Li
Published 2020-10-01

Activated spinal astrocytes contribute to the later phase of carrageenan-induced prostatitis pain

by Guo-Chuang Deng, Ming Lu, Ya-Yu Zhao, Ying Yuan, Gang Chen
Published 2019-10-01

RAM-589.555 favors neuroprotective and anti-inflammatory profile of CNS-resident glial cells in acute relapse EAE affected mice

by Rina Zilkha-Falb, Tatyana Rachutin-Zalogin, Lakota Cleaver, Michael Gurevich, Anat Achiron
Published 2020-10-01

Optical coherence tomography in myelin-oligodendrocyte-glycoprotein antibody-seropositive patients: a longitudinal study

by Frederike C. Oertel, Olivier Outteryck, Benjamin Knier, Hanna Zimmermann, Nadja Borisow, Judith Bellmann-Strobl, Astrid Blaschek, Sven Jarius, Markus Reindl, Klemens Ruprecht, Edgar Meinl, Reinhard Hohlfeld, Friedemann Paul, Alexander U. Brandt, Tania Kümpfel, Joachim Havla
Published 2019-07-01

Histamine 2/3 receptor agonists alleviate perioperative neurocognitive disorders by inhibiting microglia activation through the PI3K/AKT/FoxO1 pathway in aged rats

by Yi-Nan Chen, Huan-Huan Sha, Yi-Wei Wang, Qin Zhou, Piplu Bhuiyan, Na-Na Li, Yan-Ning Qian, Hong-Quan Dong
Published 2020-07-01

Rh-CSF1 attenuates neuroinflammation via the CSF1R/PLCG2/PKCε pathway in a rat model of neonatal HIE

by Xiao Hu, Shirong Li, Desislava Met Doycheva, Lei Huang, Cameron Lenahan, Rui Liu, Juan Huang, Shucai Xie, Jiping Tang, Gang Zuo, John H. Zhang
Published 2020-06-01

Perturbation of gut microbiota decreases susceptibility but does not modulate ongoing autoimmune neurological disease

by Clemens Gödel, Birgit Kunkel, Alireza Kashani, Hans Lassmann, Manimozhiyan Arumugam, Gurumoorthy Krishnamoorthy
Published 2020-03-01

A pivotal role for Interferon-α receptor-1 in neuronal injury induced by HIV-1

by Hina Singh, Daniel Ojeda-Juárez, Ricky Maung, Rohan Shah, Amanda J. Roberts, Marcus Kaul
Published 2020-07-01

Microstructural brain abnormalities in HIV+ individuals with or without chronic marijuana use

by Hannah A. Wang, Hua-Jun Liang, Thomas M. Ernst, Kenichi Oishi, Linda Chang
Published 2020-08-01

Anti-inflammatory and cognitive effects of interferon-β1a (IFNβ1a) in a rat model of Alzheimer’s disease

by Giuseppa Mudò, Monica Frinchi, Domenico Nuzzo, Pietro Scaduto, Fulvio Plescia, Maria F. Massenti, Marta Di Carlo, Carla Cannizzaro, Giovanni Cassata, Luca Cicero, Maria Ruscica, Natale Belluardo, Luigi M. Grimaldi
Published 2019-02-01

Therapeutic blockade of HMGB1 reduces early motor deficits, but not survival in the SOD1G93A mouse model of amyotrophic lateral sclerosis

by John D. Lee, Ning Liu, Samantha C. Levin, Lars Ottosson, Ulf Andersson, Helena E. Harris, Trent M. Woodruff
Published 2019-02-01