Inhibition of heat shock protein family A member 8 attenuates spinal cord ischemia–reperfusion injury via astrocyte NF-κB/NLRP3 inflammasome pathway

by Jingyi Mi, Yang Yang, Hao Yao, Zhirong Huan, Ce Xu, Zhiheng Ren, Wenfu Li, Ying Tang, Rao Fu, Xin Ge
Published 2021-08-01

Cathepsin H deficiency decreases hypoxia-ischemia-induced hippocampal atrophy in neonatal mice through attenuated TLR3/IFN-β signaling

by Junjun Ni, Juan Zhao, Xinwen Zhang, Thomas Reinheckel, Vito Turk, Hiroshi Nakanishi
Published 2021-08-01

Increasing toll-like receptor 2 on astrocytes induced by Schwann cell-derived exosomes promotes recovery by inhibiting CSPGs deposition after spinal cord injury

by Dayu Pan, Yongjin Li, Fuhan Yang, Zenghui Lv, Shibo Zhu, Yixin Shao, Ying Huang, Guangzhi Ning, Shiqing Feng
Published 2021-08-01

Ginsenoside Rb1 induces a pro-neurogenic microglial phenotype via PPARγ activation in male mice exposed to chronic mild stress

by Lijuan Zhang, Minmin Tang, Xiaofang Xie, Qiuying Zhao, Nan Hu, Hui He, Gangcai Liu, Shiqi Huang, Cheng Peng, Ying Xiao, Zili You
Published 2021-08-01

Recombinant annexin A2 inhibits peripheral leukocyte activation and brain infiltration after traumatic brain injury

by Ning Liu, Jinrui Han, Yadan Li, Yinghua Jiang, Samuel X. Shi, Josephine Lok, Michael Whalen, Aaron S. Dumont, Xiaoying Wang
Published 2021-08-01

Celastrol exerts a neuroprotective effect by directly binding to HMGB1 protein in cerebral ischemia–reperfusion

by Dan-Dan Liu, Piao Luo, Liwei Gu, Qian Zhang, Peng Gao, Yongping Zhu, Xiao Chen, Qiuyan Guo, Junzhe Zhang, Nan Ma, Jigang Wang
Published 2021-08-01

High-fat diet-induced diabetes leads to vascular alterations, pericyte reduction, and perivascular depletion of microglia in a 6-OHDA toxin model of Parkinson disease

by Osama F. Elabi, João Paulo M. C. M. Cunha, Abderahim Gaceb, Malin Fex, Gesine Paul
Published 2021-08-01

Aicardi-Goutières syndrome-associated mutation at ADAR1 gene locus activates innate immune response in mouse brain

by Xinfeng Guo, Clayton A. Wiley, Richard A. Steinman, Yi Sheng, Beihong Ji, Junmei Wang, Liyong Zhang, Tony Wang, Mazen Zenatai, Timothy R. Billiar, Qingde Wang
Published 2021-07-01

High-parameter cytometry unmasks microglial cell spatio-temporal response kinetics in severe neuroinflammatory disease

by Alanna G. Spiteri, Rachel L. Terry, Claire L. Wishart, Thomas M. Ashhurst, Iain L. Campbell, Markus J. Hofer, Nicholas J. C. King
Published 2021-07-01

VMP1, a novel prognostic biomarker, contributes to glioma development by regulating autophagy

by Wanzun Lin, Yun Sun, Xianxin Qiu, Qingting Huang, Lin Kong, Jiade J. Lu
Published 2021-07-01

C1q/TNF-related protein 4 restores leptin sensitivity by downregulating NF-κB signaling and microglial activation

by Liu Ye, Gongwei Jia, Yuejie Li, Ying Wang, Hong Chen, Lehua Yu, Dandong Wu
Published 2021-07-01

GPR110 ligands reduce chronic optic tract gliosis and visual deficit following repetitive mild traumatic brain injury in mice

by Huazhen Chen, Karl Kevala, Elma Aflaki, Juan Marugan, Hee-Yong Kim
Published 2021-07-01

Activation of GPR40 attenuates neuroinflammation and improves neurological function via PAK4/CREB/KDM6B pathway in an experimental GMH rat model

by Jie Xiao, Tao Cai, Yuanjian Fang, Rui Liu, Jerry J. Flores, Wenna Wang, Ling Gao, Yu Liu, Qin Lu, Lihui Tang, John H. Zhang, Hongwei Lu, Jiping Tang
Published 2021-07-01

Differential effects of the cell cycle inhibitor, olomoucine, on functional recovery and on responses of peri-infarct microglia and astrocytes following photothrombotic stroke in r...

by Wai Ping Yew, Natalia D. Djukic, Jaya S. P. Jayaseelan, Richard J. Woodman, Hakan Muyderman, Neil R. Sims
Published 2021-07-01

Expression of SARS-CoV-2-related receptors in cells of the neurovascular unit: implications for HIV-1 infection

by Silvia Torices, Rosalba Cabrera, Michael Stangis, Oandy Naranjo, Nikolai Fattakhov, Timea Teglas, Daniel Adesse, Michal Toborek
Published 2021-07-01

Thymosin β4 reverses phenotypic polarization of glial cells and cognitive impairment via negative regulation of NF-κB signaling axis in APP/PS1 mice

by Meng Wang, Li-Rong Feng, Zi-Long Li, Kai-Ge Ma, Ke-Wei Chang, Xin-Lin Chen, Peng-Bo Yang, Sheng-Feng Ji, Yan-Bing Ma, Hua Han, John Bosco Ruganzua, Wei-Na Yang, Yi-Hua Qian
Published 2021-06-01

Phloretin suppresses neuroinflammation by autophagy-mediated Nrf2 activation in macrophages

by Tess Dierckx, Mansour Haidar, Elien Grajchen, Elien Wouters, Sam Vanherle, Melanie Loix, Annick Boeykens, Dany Bylemans, Kévin Hardonnière, Saadia Kerdine-Römer, Jeroen F. J. Bogie, Jerome J. A. Hendriks
Published 2021-07-01

Cognitive and brain cytokine profile of non-demented individuals with cerebral amyloid-beta deposition

by Lisi Flores-Aguilar, M. Florencia Iulita, Chiara Orciani, Neil Tanna, Jingyun Yang, David A. Bennett, A. Claudio Cuello
Published 2021-07-01

Smek1 deficiency exacerbates experimental autoimmune encephalomyelitis by activating proinflammatory microglia and suppressing the IDO1-AhR pathway

by Ruo-Nan Duan, Chun-Lin Yang, Tong Du, Ai Liu, An-Ran Wang, Wen-Jie Sun, Xi Li, Jiang-Xia Li, Chuan-Zhu Yan, Qi-Ji Liu
Published 2021-06-01

Intracranial VCAM1 at time of mechanical thrombectomy predicts ischemic stroke severity

by Benton Maglinger, Madison Sands, Jacqueline A. Frank, Christopher J. McLouth, Amanda L. Trout, Jill M. Roberts, Stephen Grupke, Jadwiga Turchan-Cholewo, Ann M. Stowe, Justin F. Fraser, Keith R. Pennypacker
Published 2021-05-01