Article 9 human 9 mammalian target of rapamycin 8 metabolism 8 genetics 7 male 7 signal transduction 7 Akt signaling 6 Humans 6 Signal Transduction 6 controlled study 6 Animals 5 TOR Serine-Threonine Kinases 5 animal 5 down regulation 5 phosphatidylinositol 3 kinase 5 protein expression 5 protein kinase B 5 target of rapamycin kinase 5 MTOR protein, human 4 Phosphatidylinositol 3-Kinases 4 cell proliferation 4 gene expression 4 nonhuman 4 upregulation 4 Male 3 Proto-Oncogene Proteins c-akt 3 animal model 3 drug effect 3 female 3