Mitochondrial clearance of calcium facilitated by MICU2 controls insulin secretion

by N. Vishnu, A. Hamilton, A. Bagge, A. Wernersson, E. Cowan, H. Barnard, Y. Sancak, K.J. Kamer, P. Spégel, M. Fex, A. Tengholm, V.K. Mootha, D.G. Nicholls, H. Mulder
Published 2021-09-01

Single cell functional genomics reveals plasticity of subcutaneous white adipose tissue (WAT) during early postnatal development

by Elizabeth A. Rondini, Vanesa D. Ramseyer, Rayanne B. Burl, Roger Pique-Regi, James G. Granneman
Published 2021-11-01

Missense variant in insulin receptor (Y1355H) segregates in family with fatty liver disease

by Fei Luo, Chao Xing, Sumeet K. Asrani, Shili Li, Guosheng Liang, Helen H. Hobbs, Jonathan C. Cohen
Published 2021-11-01

Novel noncoding RNA CircPTK2 regulates lipolysis and adipogenesis in cachexia

by Zuoyou Ding, Diya Sun, Jun Han, Lei Shen, Fan Yang, Szechun Sah, Xiangyu Sui, Guohao Wu
Published 2021-11-01

Adipocyte CAMK2 deficiency improves obesity-associated glucose intolerance

by Wen Dai, Mayank Choubey, Sonal Patel, Harold A. Singer, Lale Ozcan
Published 2021-11-01

Correlation guided Network Integration (CoNI) reveals novel genes affecting hepatic metabolism

by Valentina S. Klaus, Sonja C. Schriever, José Manuel Monroy Kuhn, Andreas Peter, Martin Irmler, Janina Tokarz, Cornelia Prehn, Gabi Kastenmüller, Johannes Beckers, Jerzy Adamski, Alfred Königsrainer, Timo D. Müller, Martin Heni, Matthias H. Tschöp, Paul T. Pfluger, Dominik Lutter
Published 2021-11-01

β-Cell pre-mir-21 induces dysfunction and loss of cellular identity by targeting transforming growth factor beta 2 (Tgfb2) and Smad family member 2 (Smad2) mRNAs

by Sara Ibrahim, Macey Johnson, Clarissa Hernandez Stephens, Jerry Xu, Rachel Moore, Andrea Mariani, Christopher Contreras, Farooq Syed, Raghavendra G. Mirmira, Ryan M. Anderson, Emily K. Sims
Published 2021-11-01

Tissue-specific expression of Cas9 has no impact on whole-body metabolism in four transgenic mouse lines

by Simon T. Bond, Aowen Zhuang, Christine Yang, Eleanor A.M. Gould, Tim Sikora, Yingying Liu, Ying Fu, Kevin I. Watt, Yanie Tan, Helen Kiriazis, Graeme I. Lancaster, Paul Gregorevic, Darren C. Henstridge, Julie R. McMullen, Peter J. Meikle, Anna C. Calkin, Brian G. Drew
Published 2021-11-01

Physiological impact of in vivo stable isotope tracing on cancer metabolism

by Manuel Grima-Reyes, Adriana Martinez-Turtos, Ifat Abramovich, Eyal Gottlieb, Johanna Chiche, Jean-Ehrland Ricci
Published 2021-11-01

Epigenetic rewiring of skeletal muscle enhancers after exercise training supports a role in whole-body function and human health

by Kristine Williams, Germán D. Carrasquilla, Lars Roed Ingerslev, Mette Yde Hochreuter, Svenja Hansson, Nicolas J. Pillon, Ida Donkin, Soetkin Versteyhe, Juleen R. Zierath, Tuomas O. Kilpeläinen, Romain Barrès
Published 2021-11-01

Mild intermittent hypoxia exposure induces metabolic and molecular adaptations in men with obesity

by Rens L.J. van Meijel, Max A.A. Vogel, Johan W.E. Jocken, Lars M.M. Vliex, Joey S.J. Smeets, Nicole Hoebers, Joris Hoeks, Yvonne Essers, Paul F.M. Schoffelen, Henrike Sell, Sander Kersten, Kasper M.A. Rouschop, Ellen E. Blaak, Gijs H. Goossens
Published 2021-11-01

miR-126 contributes to the epigenetic signature of diabetic vascular smooth muscle and enhances antirestenosis effects of Kv1.3 blockers

by Marycarmen Arevalo-Martinez, Pilar Cidad, Sara Moreno-Estar, Mirella Fernández, Sebastian Albinsson, Irene Cózar-Castellano, José R. López-López, M. Teresa Pérez-Garcia
Published 2021-11-01

Deconstructing the origins of sexual dimorphism in sensory modulation of pancreatic β cells

by Sara McEwan, Hyokjoon Kwon, Azeddine Tahiri, Nivetha Shanmugarajah, Weikang Cai, Jin Ke, Tianwen Huang, Ariana Belton, Bhagat Singh, Le Wang, Zhiping P. Pang, Ercument Dirice, Esteban A. Engel, Abdelfattah El Ouaamari
Published 2021-11-01

The miR-200–Zeb1 axis regulates key aspects of β-cell function and survival in vivo

by Alexandra C. Title, Pamuditha N. Silva, Svenja Godbersen, Lynn Hasenöhrl, Markus Stoffel
Published 2021-11-01

Hemostatic alterations linked to body fat distribution, fatty liver, and insulin resistance

by Sebastian Hörber, Rainer Lehmann, Norbert Stefan, Jürgen Machann, Andreas L. Birkenfeld, Robert Wagner, Martin Heni, Hans-Ulrich Häring, Andreas Fritsche, Andreas Peter
Published 2021-11-01

Pioneer factor Foxa2 enables ligand-dependent activation of type II nuclear receptors FXR and LXRα

by Jessica Kain, Xiaolong Wei, Nihal A. Reddy, Andrew J. Price, Claire Woods, Irina M. Bochkis
Published 2021-11-01

Specific amino acid supplementation rescues the heart from lipid overload-induced insulin resistance and contractile dysfunction by targeting the endosomal mTOR–v-ATPase axis

by Shujin Wang, Francesco Schianchi, Dietbert Neumann, Li-Yen Wong, Aomin Sun, Frans A. van Nieuwenhoven, Maurice P. Zeegers, Agnieszka Strzelecka, Umare Col, Jan F.C. Glatz, Miranda Nabben, Joost J.F.P. Luiken
Published 2021-11-01

Role of hypothalamic de novo ceramides synthesis in obesity and associated metabolic disorders

by Christophe Magnan, Hervé Le Stunff
Published 2021-11-01

KATP channel blockers control glucagon secretion by distinct mechanisms: A direct stimulation of α-cells involving a [Ca2+]c rise and an indirect inhibition mediated by somatostati...

by Bilal Singh, Firas Khattab, Heeyoung Chae, Lieven Desmet, Pedro L. Herrera, Patrick Gilon
Published 2021-11-01

Ovarian cancer modulates the immunosuppressive function of CD11b+Gr1+ myeloid cells via glutamine metabolism

by Mary P. Udumula, Sharif Sakr, Sajad Dar, Ayesha B. Alvero, Rouba Ali-Fehmi, Eman Abdulfatah, Jing Li, Jun Jiang, Amy Tang, Thomas Buekers, Robert Morris, Adnan Munkarah, Shailendra Giri, Ramandeep Rattan
Published 2021-11-01