Adoptive T cell immunotherapy for medullary thyroid carcinoma targeting GDNF family receptor alpha 4

by Vijay G. Bhoj, Lucy Li, Kalpana Parvathaneni, Zheng Zhang, Stephen Kacir, Dimitrios Arhontoulis, Kenneth Zhou, Bevin McGettigan-Croce, Selene Nunez-Cruz, Gayathri Gulendran, Alina C. Boesteanu, Laura Johnson, Michael D. Feldman, Enrico Radaelli, Keith Mansfield, MacLean Nasrallah, Rebecca S. Goydel, Haiyong Peng, Christoph Rader, Michael C. Milone, Don L. Siegel
Published 2021-03-01

Knockdown of the DJ-1 (PARK7) gene sensitizes pancreatic cancer to erlotinib inhibition

by Xiangyi He, Yunwei Sun, Rong Fan, Jing Sun, Douwu Zou, Yaozong Yuan
Published 2021-03-01

HDAC inhibition prevents transgene expression downregulation and loss-of-function in T-cell-receptor-transduced T cells

by Tamson V. Moore, Gina M. Scurti, Matthew DeJong, Siao-Yi Wang, Annika V. Dalheim, Courtney R. Wagner, Kelli A. Hutchens, Jodi J. Speiser, Constantine V. Godellas, Chris Fountain, Jessica Fleser, Tarsem Moudgil, Mallory Thomas, David Murray, Brendan D. Curti, Joseph I. Clark, Bernard A. Fox, Michael I. Nishimura
Published 2021-03-01

Tumor microenvironment and immune-related therapies of head and neck squamous cell carcinoma

by Yixiao Qin, Xiwang Zheng, Wei Gao, Binquan Wang, Yongyan Wu
Published 2021-03-01

Eliminating mesothelioma by AAV-vectored, PD1-based vaccination in the tumor microenvironment

by Zhiwu Tan, Mei Sum Chiu, Chi Wing Yan, Kwan Man, Zhiwei Chen
Published 2021-03-01

Efficient antitumor effects of a novel oncolytic adenovirus fully composed of species B adenovirus serotype 35

by Ryosuke Ono, Kosuke Takayama, Fuminori Sakurai, Hiroyuki Mizuguchi
Published 2021-03-01

Real-time visualization of intratumoral necrosis using split-luciferase reconstitution by protein trans-splicing

by Go Kagiya, Ayaka Sato, Ryohei Ogawa, Masanori Hatashita, Mana Kato, Makoto Kubo, Fumiaki Kojima, Fumitaka Kawakami, Yukari Nishimura, Naoya Abe, Fuminori Hyodo
Published 2021-03-01

Classification of pediatric gliomas based on immunological profiling: implications for immunotherapy strategies

by Zihao Wang, Xiaopeng Guo, Lu Gao, Yu Wang, Yi Guo, Bing Xing, Wenbin Ma
Published 2021-03-01

Anti-oncogenic activities exhibited by paracrine factors of MSCs can be mediated by modulation of KITLG and DKK1 genes in glioma SCs in vitro

by Nazneen Aslam, Elham Abusharieh, Duaa Abuarqoub, Dema Ali, Dana Al-Hattab, Suha Wehaibi, Ban Al-Kurdi, Fatima Jamali, Walhan Alshaer, Hanan Jafar, Abdalla S. Awidi
Published 2021-03-01

microRNA-130b-3p Contained in MSC-Derived EVs Promotes Lung Cancer Progression by Regulating the FOXO3/NFE2L2/TXNRD1 Axis

by Quanwei Guo, Jun Yan, Tieniu Song, Chenghua Zhong, Jun Kuang, Yijun Mo, Jianfeng Tan, Dongfang Li, Zesen Sui, Kaican Cai, Jianhua Zhang
Published 2021-03-01

Negative allosteric modulators of metabotropic glutamate receptor 3 target the stem-like phenotype of glioblastoma

by Hans-Georg Wirsching, Manuela Silginer, Elisa Ventura, Will Macnair, Isabel Burghardt, Manfred Claassen, Silvia Gatti, Jürgen Wichmann, Claus Riemer, Hannah Schneider, Michael Weller
Published 2021-03-01

Phase I trial of oncolytic adenovirus-mediated cytotoxic and interleukin-12 gene therapy for the treatment of metastatic pancreatic cancer

by Kenneth N. Barton, Farzan Siddiqui, Robert Pompa, Svend O. Freytag, Gazala Khan, Irina Dobrosotskaya, Munther Ajlouni, Yingshu Zhang, Jingfang Cheng, Benjamin Movsas, David Kwon
Published 2021-03-01

Recombinant oncolytic adenovirus expressing a soluble PVR elicits long-term antitumor immune surveillance

by Hailin Zhang, Yonghui Zhang, Jie Dong, Binghua Li, Chun Xu, Min Wei, Junhua Wu, Jiwu Wei
Published 2021-03-01

Single-cell RNA-sequencing analyses identify heterogeneity of CD8+ T cell subpopulations and novel therapy targets in melanoma

by Weiwei Deng, Yubo Ma, Zhen Su, Yufang Liu, Panpan Liang, Chen Huang, Xiao Liu, Jin Shao, Yi Zhang, Kai Zhang, Jian Chen, Ruoyu Li
Published 2021-03-01

Therapeutic potential of IBP as an autophagy inducer for treating lung cancer via blocking PAK1/Akt/mTOR signaling

by Huimin Bu, Shirui Tan, Bo Yuan, Xiaomei Huang, Jiebang Jiang, Yejiao Wu, Jihong Jiang, Rongpeng Li
Published 2021-03-01

Association between NER pathway gene polymorphisms and neuroblastoma risk in an eastern Chinese population

by Chunlei Zhou, Yizhen Wang, Lili He, Jinhong Zhu, Jinghang Li, Yingzi Tang, Haixia Zhou, Jing He, Haiyan Wu
Published 2021-03-01

Metformin enhances anti-cancer effects of cisplatin in meningioma through AMPK-mTOR signaling pathways

by Liemei Guo, Jing Cui, Herui Wang, Rogelio Medina, Shilei Zhang, Xiaohua Zhang, Zhengping Zhuang, Yingying Lin
Published 2021-03-01

CXCL2 combined with HVJ-E suppresses tumor growth and lung metastasis in breast cancer and enhances anti-PD-1 antibody therapy

by Yi Chun Pan, Tomoyuki Nishikawa, Chin Yang Chang, Jiayu A. Tai, Yasufumi Kaneda
Published 2021-03-01

A novel vaccinia virus enhances anti-tumor efficacy and promotes a long-term anti-tumor response in a murine model of colorectal cancer

by Na Wang, Jiwei Wang, Zhe Zhang, Hua Cao, Wenli Yan, Yongchao Chu, Louisa S. Chard Dunmall, Yaohe Wang
Published 2021-03-01

Local administration of IL-12 with an HC vector results in local and metastatic tumor control in pediatric osteosarcoma

by Marta Zalacain, María Bunuales, Lucía Marrodan, Sara Labiano, Marisol Gonzalez-Huarriz, Naiara Martinez-Vélez, Virginia Laspidea, Montse Puigdelloses, Marc García-Moure, Manuela Gonzalez-Aparicio, Rubén Hernandez-Alcoceba, Marta M. Alonso, Ana Patiño-García
Published 2021-03-01