Selective Closed-State Nav1.7 Blocker JZTX-34 Exhibits Analgesic Effects against Pain

by Xiongzhi Zeng, Pengpeng Li, Bo Chen, Juan Huang, Ren Lai, Jingze Liu, Mingqiang Rong
Published 2018-02-01

Structure-based assessment of disease-related mutations in human voltage-gated sodium channels

by Weiyun Huang, Minhao Liu, S. Frank Yan, Nieng Yan
Published 2017-02-01

Development of a Rapid Throughput Assay for Identification of hNav1.7 Antagonist Using Unique Efficacious Sodium Channel Agonist, Antillatoxin

by Fang Zhao, Xichun Li, Liang Jin, Fan Zhang, Masayuki Inoue, Boyang Yu, Zhengyu Cao
Published 2016-02-01

Sensitization of dural afferents underlies migraine-related behavior following meningeal application of interleukin-6 (IL-6)

by Yan Jin, Melemedjian Ohannes K, Price Theodore J, Dussor Gregory
Published 2012-01-01

Conserved Expression of Nav1.7 and Nav1.8 Contribute to the Spontaneous and Thermally Evoked Excitability in IL-6 and NGF-Sensitized Adult Dorsal Root Ganglion Neurons In Vitro

by Rahul R. Atmaramani, Bryan J. Black, June Bryan de la Peña, Zachary T. Campbell, Joseph J. Pancrazio
Published 2020-05-01

Sensitization of dural afferents underlies migraine-related behavior following meningeal application of interleukin-6 (IL-6)

by Yan, Jin, Melemedjian, Ohannes, Price, Theodore, Dussor, Gregory
Published 2012

Functional confirmation that the R1488* variant in SCN9A results in complete loss-of-function of Nav1.7

by Wen He, Gareth T. Young, Baohong Zhang, Peter J. Cox, Lily Ting-Yin Cho, Sally John, Sara A. Paciga, Linda S. Wood, Nicolas Danziger, Serena Scollen, Ciara Vangjeli
Published 2018-07-01

A mini-review: Bridging the gap between autism spectrum disorder and pain comorbidities

by Chad O. Brown, Jarryll Uy, Karun K. Singh
Published 2020-12-01

Sodium channels and mammalian sensory mechanotransduction

by Raouf Ramin, Rugiero Francois, Kiesewetter Hannes, Hatch Rachel, Hummler Edith, Nassar Mohammed A, Wang Fan, Wood John N
Published 2012-03-01

Discovery of a Novel Nav1.7 Inhibitor From Cyriopagopus albostriatus Venom With Potent Analgesic Efficacy

by Yunxiao Zhang, Dezheng Peng, Biao Huang, Qiuchu Yang, Qingfeng Zhang, Minzhi Chen, Mingqiang Rong, Zhonghua Liu
Published 2018-10-01

Membrane protein Nav1.7 contributes to the persistent post-surgical pain regulated by p-p65 in dorsal root ganglion (DRG) of SMIR rats model

by Zhisong Li, Yaru Li, Jing Cao, Xuemin Han, Weihua Cai, Weidong Zang, Jitian Xu, Wei Zhang
Published 2017-11-01

Synthesis and Analgesic Effects of μ-TRTX-Hhn1b on Models of Inflammatory and Neuropathic Pain

by Yu Liu, Jianguang Tang, Yunxiao Zhang, Xiaohong Xun, Dongfang Tang, Dezheng Peng, Jianming Yi, Zhonghua Liu, Xiaoliu Shi
Published 2014-08-01

Expression of NaV-1.7, TNF-α and HSP-70 in experimental flare-up post-extirpated dental pulp tissue through a neuroimmunological approach

by Galih Sampoerno, Jenny Sunariani, Kuntaman
Published 2020-05-01

Glial interleukin-1β upregulates neuronal sodium channel 1.7 in trigeminal ganglion contributing to temporomandibular joint inflammatory hypernociception in rats

by Peng Zhang, Rui-Yun Bi, Ye-Hua Gan
Published 2018-04-01

Newly Discovered Action of HpTx3 from Venom of Heteropoda <i>venatoria </i>on Na_v1.7 and Its Pharmacological Implications in Analgesia

by Xinzhou Wu, Zhouquan Wang, Yu Chen, Dehong Xu, Peng Zhang, Xianchun Wang
Published 2019-11-01

Inhibition of voltage-gated sodium channels by sumatriptan bioisosteres

by Roberta eCarbonara, Alessia eCarocci, Julien eRoussel, Giuseppe eCrescenzo, Canio eBuonavoglia, Carlo eFranchini, Giovanni eLentini, Diana eConte Camerino, Jean-François eDesaphy
Published 2015-07-01

Investigation of Binding Modes and Functional Surface of Scorpion Toxins ANEP to Sodium Channels 1.7

by Yongbo Song, Zeyu Liu, Qi Zhang, Chunming Li, Wei Jin, Lili Liu, Jianye Zhang, Jinghai Zhang
Published 2017-11-01

UNDERSTANDING THE PATHOPHYSIOLOGY OF MIGRAINE: ACTIVATION AND SENSITIZATION OF DURAL AFFERENTS

by Yan, Jin
Published 2011

Novel charged sodium and calcium channel inhibitor active against neurogenic inflammation

by Seungkyu Lee, Sooyeon Jo, Sébastien Talbot, Han-Xiong Bear Zhang, Masakazu Kotoda, Nick A Andrews, Michelino Puopolo, Pin W Liu, Thomas Jacquemont, Maud Pascal, Laurel M Heckman, Aakanksha Jain, Jinbo Lee, Clifford J Woolf, Bruce P Bean
Published 2019-11-01

Recent developments regarding voltage-gated sodium channel blockers for the treatment of inherited and acquired neuropathic pain syndromes

by Jonathan W. Theile, Theodore R Cummins
Published 2011-10-01