Pharmacokinetic and pharmacodynamic modeling of oral mitiglinide on glucose lowering in healthy Chinese volunteers

by Shijia Liu, Peidong Chen, Yang Zhao, Guoliang Dai, Bingting Sun, Yao Wang, Anwei Ding, Wenzheng Ju
Published 2017-07-01

Accelerating Development of Benziamidazole-Class Proton Pump Inhibitors: A Mechanism-Based PK/PD Model to Optimize Study Design with Ilaprazole as a Case Drug

by Ranran Jia, Fan Zhang, Ni Wu, Wen Xu, Huitao Gao, Bo Liu, Hongyun Wang
Published 2021-03-01

Pharmacokinetic-Pharmacodynamic Modeling to Study the Antipyretic Effect of Qingkailing Injection on Pyrexia Model Rats

by Zhixin Zhang, Lingling Qin, Long Peng, Qingqing Zhang, Qing Wang, Zhiwei Lu, Yuelin Song, Xiaoyan Gao
Published 2016-03-01

EEG entropy measures in anesthesia

by Zhenhu eLiang, Yinghua eWang, Yinghua eWang, Xue eSun, Duan eLi, Logan James Voss, Jamie eSleigh, Satoshi eHagihira, Xiaoli eLi, Xiaoli eLi
Published 2015-02-01

Pharmacokinetic–Pharmacodynamic Model for the Testosterone-Suppressive Effect of Leuprolide in Normal and Prostate Cancer Rats

by Dong-Seok Lee, Sook-Jin Kim, Go-Wun Choi, Yong-Bok Lee, Hea-Young Cho
Published 2018-04-01

Assessing the utility of an anti-malarial pharmacokinetic-pharmacodynamic model for aiding drug clinical development

by Zaloumis Sophie, Humberstone Andrew, Charman Susan A, Price Ric N, Moehrle Joerg, Gamo-Benito Javier, McCaw James, Jamsen Kris M, Smith Katherine, Simpson Julie A
Published 2012-08-01

Evaluating Pharmacokinetic and Pharmacodynamic Interactions with Computational Models in Supporting Cumulative Risk Assessment

by Jerry Campbell, Melvin Andersen, Yu-Mei Tan, Harvey Clewell
Published 2011-05-01

Cellular uptake and efflux of palbociclib in vitro in single cell and spheroid models

by Jove, M., Spencer, Jade A., Hubbard, M.E., Holden, E.C., O'Dea, R.D., Brook, B.S., Phillips, Roger M., Smye, S.W., Loadman, Paul M., Twelves, C.J.
Published 2019

Changing the Drug Delivery System: Does It Add to Non-Compliance Ramifications Control? A Simulation Study on the Pharmacokinetics and Pharmacodynamics of Atypical Antipsychotic Dr...

by Mohammed H. Elkomy
Published 2020-03-01

Rapid quantitative pharmacodynamic imaging by a novel method: theory, simulation testing and proof of principle

by Kevin J. Black, Jonathan M. Koller, Brad D. Miller
Published 2013-08-01

Glibenclamide population pharmacokinetic/pharmacodynamic modeling in South African type 2 diabetic subjects

by Rambiritch V, Naidoo P, Pillai G
Published 2016-09-01

A fuzzy logic controller for intestinal levodopa infusion in Parkinson’s disease

by Jiang, Xiaowen
Published 2010

Semi-Mechanistic Modeling of HY-021068 Based on Irreversible Inhibition of Thromboxane Synthetase

by Ping Li, Jie Huang, Donghao Geng, Peihua Liu, Zhaoxing Chu, Jianjun Zou, Guoping Yang, Li Liu
Published 2020-11-01

Corrigendum: Predicting the Effects of CYP2C19 and Carboxylesterases on Vicagrel, a Novel P2Y12 Antagonist, by Physiologically Based Pharmacokinetic/Pharmacodynamic Modeling Approa...

by Shuaibing Liu, Ziteng Wang, Xin Tian, Weimin Cai
Published 2021-04-01

Predicting the Effects of CYP2C19 and Carboxylesterases on Vicagrel, a Novel P2Y12 Antagonist, by Physiologically Based Pharmacokinetic/Pharmacodynamic Modeling Approach

by Shuaibing Liu, Ziteng Wang, Xin Tian, Weimin Cai
Published 2020-12-01

Intracellular PD Modelling (<i>PD</i>_i) for the Prediction of Clinical Activity of Increased Rifampicin Dosing

by Ghaith Aljayyoussi, Samantha Donnellan, Stephen A. Ward, Giancarlo A. Biagini
Published 2019-06-01

The Steps to Therapeutic Drug Monitoring: A Structured Approach Illustrated With Imatinib

by Thierry Buclin, Yann Thoma, Nicolas Widmer, Nicolas Widmer, Nicolas Widmer, Pascal André, Monia Guidi, Monia Guidi, Chantal Csajka, Chantal Csajka, Laurent A. Decosterd
Published 2020-03-01

Pharmacokinetic-Pharmacodynamic Modelling of Systemic IL13 Blockade by Monoclonal Antibody Therapy: A Free Assay Disguised as Total

by John Hood, Ignacio González-García, Nicholas White, Leeron Marshall, Vincent F. S. Dubois, Paolo Vicini, Paul G. Baverel
Published 2021-04-01

Characterization of novel PI3Kδ inhibitors as potential therapeutics for SLE and lupus nephritis in pre-clinical studies

by Philipp eHaselmayer, Montserrat eCamps, Mathilde eMuzerelle, Mathilde eMuzerelle, Samer eEl Bawab, Caroline eWaltzinger, Caroline eWaltzinger, Lisa eBruns, Nada eAbla, Mark ePolokoff, Carole eJond-Necand, Marilène eGaudet, Audery eBenoit, Dominique eBertschy Meier, Catherine eMartin, Denise eGretener, Maria Stella Lombardi, Maria Stella Lombardi, Roland eGrenningloh, Christoph eLadel, Jørgen Søberg Petersen, Jørgen Søberg Petersen, Pascale eGaillard, Pascale eGaillard, Hong eJi, Hong eJi
Published 2014-05-01

Optimal empiric treatment for KPC-2-producing Klebsiella pneumoniae infections in critically ill patients with normal or decreased renal function using Monte Carlo simulation

by Guoan Wang, Wei Yu, Yushan Cui, Qingyi Shi, Chen Huang, Yonghong Xiao
Published 2021-03-01