human 484 genetics 422 Humans 401 Article 400 controlled study 295 metabolism 236 nonhuman 219 RNA 205 male 193 female 188 gene expression 179 adult 160 microRNA 147 unclassified drug 144 messenger RNA 131 Female 124 Animals 121 animal 119 Male 118 pathology 112 gene expression regulation 111 MicroRNAs 109 human cell 101 middle aged 94 RNA sequencing 93 protein expression 91 real time polymerase chain reaction 90 upregulation 90 Middle Aged 87 major clinical study 86